In striated muscle, the protein troponin complex turns contraction on and off in a calcium-
dependent manner. The calcium-sensing component of the complex is troponin C, which is …

Troponin (Tn) is a critical regulator of muscle contraction in cardiac muscle. Mutations in Tn
subunits are associated with hypertrophic, dilated and restrictive cardiomyopathies …

Background Cardiac diffusion tensor imaging (cDTI) measures the magnitudes and
directions of intramyocardial water diffusion. Assuming the cross-myocyte components to be …

Cardiac muscle contraction occurs due to repetitive interactions between myosin thick and
actin thin filaments (TF) regulated by Ca 2+ levels, active cross-bridges, and cardiac myosin …

The current repertoire of HCM genes allows effective gene-based diagnosis, information that
enables accurate assessment of disease risk in family members, and provides some insight …

All muscle contraction occurs due to the cyclical interaction between sarcomeric thin and
thick filament proteins within the myocyte. The thin filament consists of the proteins actin …

Cardiomyopathy is defined as a disease of functional impairment in the cardiac muscle and
its etiology includes both extrinsic and intrinsic factors. Cardiomyopathy caused by the …

The sarcomere as the smallest contractile unit is prone to alterations in its functional,
structural and associated proteins. Sarcomeric dysfunction leads to heart failure or …

Rationale: The regulation of calcium (Ca2+) homeostasis by β-adrenergic receptor (βAR)
activation provides the essential underpinnings of sympathetic regulation of myocardial …

Introduction Troponin (TNN)-encoded cardiac troponins (Tn) are critical for sensing calcium
and triggering myofilament contraction. TNN variants are associated with development of …