The past decade has witnessed significant advances in the systemic treatment of advanced
hepatocellular carcinoma (HCC). Nevertheless, the newly developed treatment strategies …

Liver cancer, primarily HCC, exhibits highly heterogeneous histological and molecular
aberrations across tumors and within individual tumor nodules. Such intertumor and …

Metabolic reprogramming is a hallmark of cancer. However, mechanisms underlying
metabolic reprogramming and how altered metabolism in turn enhances tumorigenicity are …

The development of liver-based adeno-associated virus (AAV) gene therapies is facing
concerns about limited efficiency and durability of transgene expression. We evaluated …

Myeloid cells are abundant and plastic immune cell subsets in the liver, to which pro-
tumorigenic, inflammatory and immunosuppressive roles have been assigned in the course …

Dysregulation of WNT/β-catenin is a hallmark of many cancer types and a key mediator of
metastasis in solid tumors. Overactive β-catenin signaling hampers dendritic cell (DC) …

Obesity is related to several organs, but the liver is particularly affected. Adenosine
monophosphate‐activated protein kinase (AMPK) is a cellular energy sensor and regulator …

Cell fate plasticity enables development, yet unlocked plasticity is a cancer hallmark. While
transcription master regulators induce lineage-specific genes to restrict plasticity, it remains …

Hepatology AASLD Publications Hepatology Liver Transplantation Clinical Liver Disease
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