Solute carrier (SLC) membrane transport proteins control essential physiological functions,
including nutrient uptake, ion transport, and waste removal. SLCs interact with several …

The field of transport biology has steadily grown over the past decade and is now
recognized as playing an important role in manifestation and treatment of disease. The SLC …

Do the amino acid sequence identities of residues that make contact across protein
interfaces covary during evolution? If so, such covariance could be used to predict contacts …

The determination of the crystal structures of small-molecule transporters has shed light on
the conformational changes that take place during structural isomerization from outward-to …

The emergence and spread of drug-resistant Plasmodium falciparum impedes global efforts
to control and eliminate malaria. For decades, treatment of malaria has relied on …

The human solute carrier (SLC) transporters are important targets for drug development.
Structure-based drug discovery for SLC transporters requires the description of their …

Membrane transporters are integral membrane proteins that mediate the passage of solutes
across lipid bilayers. These proteins undergo conformational transitions between outward …

Citrate is best known as an intermediate in the tricarboxylic acid cycle of the cell. In addition
to this essential role in energy metabolism, the tricarboxylate anion also acts as both a …

SbtA is a high-affinity, sodium-dependent bicarbonate transporter found in the
cyanobacterial CO2-concentrating mechanism (CCM). SbtA forms a complex with SbtB …

Citrate, α-ketoglutarate and succinate are TCA cycle intermediates that also play essential
roles in metabolic signaling and cellular regulation. These di-and tricarboxylates are …