Asthma and chronic obstructive pulmonary disease (COPD) are very common inflammatory
diseases of the airways. They both cause airway narrowing and are increasing in incidence …

While asthma is considered an inflammatory disorder of the conducting airways, it is
becoming increasingly apparent that the disease is heterogeneous with respect to …

Background Immune anomalies have been documented in individuals with autism spectrum
disorders (ASDs) and their family members. It is unknown whether the maternal immune …

Abstract IL-33 is an IL-1 family member recently identified as the ligand for T1/ST2 (ST2), a
member of the IL-1 receptor family. ST2 is stably expressed on mast cells and Th2 effector T …

Ovalbumin challenge models of asthma offer many opportunities for increasing our
understanding of the pathogenetic mechanisms underlying this disease, as well as for …

In this review, we highlight experiments conducted in our laboratories that have elucidated
functional roles for CD 4+ T‐helper type‐2 lymphocytes (TH 2 cells), their associated …

Advances have been made in defining the mechanisms for the control of allergic airway
inflammation in response to inhaled antigens. Several genes, including ADAM33, DPP10 …

Background Asthma is estimated to affect as many as 300 million people worldwide and its
incidence and prevalence are rapidly increasing throughout the world, especially in children …

Development of persistent Th2 responses in asthma and chronic helminth infections are a
major health concern. IL-10 has been identified as a critical regulator of Th2 immunity, but …

Introduction: Neutrophilic airway inflammation represents a pathologically distinct form of
asthma and frequently appears in symptomatic adulthood asthmatics. However, clinical …