Interplay between mechanics and signalling in regulating cell fate

H De Belly, EK Paluch, KJ Chalut - Nature Reviews Molecular Cell …, 2022 - nature.com
Mechanical signalling affects multiple biological processes during development and in adult
organisms, including cell fate transitions, cell migration, morphogenesis and immune …

Insight into cellular uptake and intracellular trafficking of nanoparticles

P Foroozandeh, AA Aziz - Nanoscale research letters, 2018 - Springer
Nanoparticle science is rapidly changing the landscape of various scientific fields and
defining new technological platforms. This is perhaps even more evident in the field of …

Advances in fatty acids nutrition in dairy cows: from gut to cells and effects on performance

M Bionaz, E Vargas-Bello-Pérez, S Busato - Journal of Animal Science …, 2020 - Springer
High producing dairy cows generally receive in the diet up to 5–6% of fat. This is a relatively
low amount of fat in the diet compared to diets in monogastrics; however, dietary fat is …

Bacterial membranes: structure, domains, and function

H Strahl, J Errington - Annual review of microbiology, 2017 - annualreviews.org
The bacterial cytoplasmic membrane is composed of roughly equal proportions of lipids and
proteins. The main lipid components are phospholipids, which vary in acyl chain length …

Mechanosensitive membrane domains regulate calcium entry in arterial endothelial cells to protect against inflammation

SG Hong, JW Ashby, JP Kennelly, M Wu, M Steel… - The Journal of Clinical …, 2024 - jci.org
Endothelial cells (ECs) in the descending aorta are exposed to high laminar shear stress,
and this supports an antiinflammatory phenotype. High laminar shear stress also induces …

Multifaceted cargo recruitment and release from artificial membraneless organelles

J Liu, F Zhorabek, T Zhang, JWY Lam, BZ Tang… - Small, 2022 - Wiley Online Library
Liquid‐liquid phase separation (LLPS) drives membraneless organelles (MLOs) formation
for organizing biomolecules. Artificial MLOs (AMLOs) have been constructed mostly via the …

Cryo-EM architecture of a near-native stretch-sensitive membrane microdomain

JM Kefauver, M Hakala, L Zou, J Alba, J Espadas… - Nature, 2024 - nature.com
Biological membranes are partitioned into functional zones termed membrane
microdomains, which contain specific lipids and proteins,–. The composition and …

[HTML][HTML] GPCRs in intracellular compartments: new targets for drug discovery

I Fasciani, M Carli, F Petragnano, F Colaianni, G Aloisi… - Biomolecules, 2022 - mdpi.com
The architecture of eukaryotic cells is defined by extensive membrane-delimited
compartments, which entails separate metabolic processes that would otherwise interfere …

Defining raft domains in the plasma membrane

A Kusumi, TK Fujiwara, TA Tsunoyama, RS Kasai… - Traffic, 2020 - Wiley Online Library
Many plasma membrane (PM) functions depend on the cholesterol concentration in the PM
in strikingly nonlinear, cooperative ways: fully functional in the presence of physiological …

[HTML][HTML] Four-color single-molecule imaging with engineered tags resolves the molecular architecture of signaling complexes in the plasma membrane

JS Bellón, O Birkholz, CP Richter, F Eull… - Cell reports …, 2022 - cell.com
Localization and tracking of individual receptors by single-molecule imaging opens unique
possibilities to unravel the assembly and dynamics of signaling complexes in the plasma …