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Ageing, cellular senescence and neurodegenerative disease
Ageing is a major risk factor for develo** many neurodegenerative diseases. Cellular
senescence is a homeostatic biological process that has a key role in driving ageing. There …
senescence is a homeostatic biological process that has a key role in driving ageing. There …
Cellular senescence in neurodegenerative diseases
C Martínez-Cué, N Rueda - Frontiers in cellular neuroscience, 2020 - frontiersin.org
Cellular senescence is a homeostatic biological process characterized by a permanent state
of cell cycle arrest that can contribute to the decline of the regenerative potential and …
of cell cycle arrest that can contribute to the decline of the regenerative potential and …
Cellular senescence and cardiovascular diseases: moving to the “heart” of the problem
Cardiovascular diseases (CVDs) constitute the prime cause of global mortality, with an
immense impact on patient quality of life and disability. Clinical evidence has revealed a …
immense impact on patient quality of life and disability. Clinical evidence has revealed a …
Induction of APOBEC3 exacerbates DNA replication stress and chromosomal instability in early breast and lung cancer evolution
APOBEC3 enzymes are cytosine deaminases implicated in cancer. Precisely when
APOBEC3 expression is induced during cancer development remains to be defined. Here …
APOBEC3 expression is induced during cancer development remains to be defined. Here …
Escape from senescence: molecular basis and therapeutic ramifications
K Evangelou, K Belogiannis… - The Journal of …, 2023 - Wiley Online Library
Cellular senescence constitutes a stress response mechanism in reaction to a plethora of
stimuli. Senescent cells exhibit cell‐cycle arrest and altered function. While cell‐cycle …
stimuli. Senescent cells exhibit cell‐cycle arrest and altered function. While cell‐cycle …
Pulmonary infection by SARS-CoV-2 induces senescence accompanied by an inflammatory phenotype in severe COVID-19: possible implications for viral …
K Evangelou, D Veroutis, K Paschalaki… - European …, 2022 - publications.ersnet.org
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of
the respiratory system can progress to a multisystemic disease with aberrant inflammatory …
the respiratory system can progress to a multisystemic disease with aberrant inflammatory …
Mechanisms of genomic instability in breast cancer
Breast cancer is the most common cancer among women globally. Genomic instability (GI)
refers to the increased tendency to accrue genomic alterations. It drives heterogeneity and is …
refers to the increased tendency to accrue genomic alterations. It drives heterogeneity and is …
[HTML][HTML] Senescence and senotherapeutics: a new field in cancer therapy
Cellular senescence is a stress response mechanism ensuring homeostasis. Its temporal
activation during embryonic development or normal adult life is linked with beneficial …
activation during embryonic development or normal adult life is linked with beneficial …
[HTML][HTML] A fluorophore-conjugated reagent enabling rapid detection, isolation and live tracking of senescent cells
S Magkouta, D Veroutis, A Pousias… - Molecular Cell, 2023 - cell.com
Cellular senescence is a stress-response mechanism implicated in various physiological
processes, diseases, and aging. Current detection approaches have partially addressed the …
processes, diseases, and aging. Current detection approaches have partially addressed the …
Machine learning and data mining frameworks for predicting drug response in cancer: An overview and a novel in silico screening process based on association rule …
A major challenge in cancer treatment is predicting the clinical response to anti-cancer
drugs on a personalized basis. The success of such a task largely depends on the ability to …
drugs on a personalized basis. The success of such a task largely depends on the ability to …