The discovery in 2006 that loss-of-function mutations in the filaggrin gene (FLG) cause
ichthyosis vulgaris and can predispose to atopic dermatitis (AD) galvanized the dermatology …

Allergies, including asthma, food allergy and atopic dermatitis, are increasing in prevalence,
particularly in westernized countries. Although a detailed mechanistic explanation for this …

Since the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967,
our knowledge about the immunological mechanisms of IgE‐mediated allergies has …

The atopic march recognizes the increased occurrence of asthma, allergic rhinitis, or both
after atopic dermatitis (AD) onset. Mechanisms for develo** atopic comorbidities after AD …

Objective To provide an overview of filaggrin biology and the role of filaggrin variants in
atopic dermatitis (AD) and allergic disease. Data Sources We performed a PubMed literature …

Background Skin barrier dysfunction precedes eczema development. We tested whether
daily use of emollient in the first year could prevent eczema in high-risk children. Methods …

There is increasing evidence regarding the importance of allergic sensitization through the
skin. In this review, we provide an overview of the atopic march and immune mechanism …

abstract Five years have passed since the Japanese Pediatric Guideline for Food Allergy
(JPGFA) was first revised in 2011 from its original version. As many scientific papers related …

Atopic dermatitis (AD) is a complex skin disease frequently associated with other diseases of
the atopic diathesis. Recent evidence supports the concept that AD can also recognize other …

Many consider food allergy as the" second wave" of the allergy epidemic following the" first
wave" of respiratory allergy, ie, asthma and allergic rhinitis, plaguing westernized countries …