CRISPR-Cas technology has revolutionized biological research and holds great therapeutic
potential. Here, we review CRISPR-Cas systems and their latest developments with an …

The rapid development of genome editing technology has brought major breakthroughs in
the fields of life science and medicine. In recent years, the clustered regularly interspaced …

Aims Genetic dilated cardiomyopathy (DCM) is a leading cause of heart failure. Despite
significant progress in understanding the genetic aetiologies of DCM, the molecular …

Background: Phospholamban (PLN) is a critical regulator of calcium cycling and contractility
in the heart. The loss of arginine at position 14 in PLN (R14del) is associated with dilated …

Background Dilated cardiomyopathy (DCM), characterized by progressive left ventricular
enlargement and systolic dysfunction, is the most common type of cardiomyopathy and a …

Doxorubicin is limited in its therapeutic utility due to its life-threatening cardiovascular side
effects. Here, we present an integrated drug discovery pipeline combining human induced …

The development of gene-editing technology has been one of the biggest advances in
biomedicine over the past two decades. Not only can it be used as a research tool to build a …

Centronuclear myopathy (CNM) is a congenital neuromuscular disorder caused by
pathogenic variation in genes associated with membrane trafficking and excitation …

SPEG (Striated Preferentially Expressed Pro-tein Kinase), a member of the myosin light
chain kinase family, is critical for cardiac and skeletal muscle function involved in excitation …

Genetic cardiomyopathies represent a wide spectrum of inherited diseases and constitute
an important cause of morbidity and mortality among young people, which can manifest with …