In 2000, the third member of the globin family was discovered in human and mouse brain
and named neuroglobin (Ngb). Ngb is a monomeric 3/3 globin structurally similar to …

Estradiol exerts neuroprotective actions that are mediated by the regulation of a variety of
signaling pathways and homeostatic molecules. Among these is neuroglobin, which is …

CNS ischemia results in locally confined and rapid tissue damage accompanied by a loss of
neurons and their circuits. Early and time-delayed inflammatory responses are critical …

Abstract Background and Purpose Curcumin, a natural antioxidant isolated from Curcuma
longa, has been reported to exert neuroprotective effect in animal models of ischemic stroke …

Oxidative stress, resulting from accumulation of reactive oxygen species, plays a critical role
in astroglial cell death occurring in diverse neuropathological conditions. Numerous studies …

Previous studies show that caspase-6 and caspase-8 are involved in neuronal apoptosis
and regenerative failure after trauma of the adult central nervous system (CNS). In this study …

Protein design has received much attention in the last decades. With an additional disulfide
bond to enhance the protein stability, human A15C neuroglobin (Ngb) is an ideal protein …

Neuroglobin (Ngb) has been demonstrated by our lab and others to be neuroprotective
against neurological disorders including stroke. However, the roles of Ngb in neurogenesis …

Abstract Alzheimer's disease (AD), the most common type of dementia, is a devastating
neurodegenerative disease characterized by progressive neuro-cognitive dysfunction. In our …

Neuroglobin (NGB) is an O2-binding globin mainly expressed in the central and peripheral
nervous systems and cerebrospinal fluid. Previously, it was demonstrated that NGB …