Introduction: Spirooxindole, a unique and versatile scaffold, has been widely studied in
some fields such as pharmaceutical chemistry and synthetic chemistry. Especially in the …

Oxindole derivatives are known for their great interest in the field of Medicinal Chemistry, as
they display vast biological activities. Recent efforts concerning the preparation of oxindole …

Leishmaniasis, a category 1 neglected protozoan disease caused by a kinetoplastid
pathogen called Leishmania, is transmitted through dipteran insect vectors (phlebotomine …

Leishmaniasis is a neglected tropical disease with no effective vaccines to date. Globally, it
affects around 14 million people living in undeveloped and develo** countries …

Prevention, accurate diagnosis, and effective treatment of infections are the main challenges
in the overall management of infectious diseases. The best example is the ongoing SARs …

An efficient method to construct unique spiro [indoline-3, 4′-pyrrolo [3, 4-b] pyridines] was
successfully developed via a DABCO promoted formal [3+ 3] cycloaddition reaction of MBH …

Human protozoan diseases represent a serious health problem worldwide, affecting mainly
people in social and economic vulnerability. These diseases have attracted little investment …

Leishmaniasis is a neglected tropical disease, and there is an emerging need for the
development of effective drugs to treat it. To identify novel compounds with antileishmanial …

Isatin derivatives potentially act on various biological targets. In this article, a series of novel
isatin-hydrazones were synthesized in excellent yields. Their cytotoxicity was tested against …

Leishmaniasis is a tropical disease caused by a protozoan parasite Leishmania that is
transmitted via infected female sandflies. At present, leishmaniasis treatment mainly counts …