Dentate gyrus circuits for encoding, retrieval and discrimination of episodic memories
The dentate gyrus (DG) has a key role in hippocampal memory formation. Intriguingly, DG
lesions impair many, but not all, hippocampus-dependent mnemonic functions, indicating …
lesions impair many, but not all, hippocampus-dependent mnemonic functions, indicating …
BACE1 physiological functions may limit its use as therapeutic target for Alzheimer's disease
S Barão, D Moechars, SF Lichtenthaler… - Trends in …, 2016 - cell.com
The protease β-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) is required
for the production of the amyloid-β (Aβ) peptide, which is central to the pathogenesis of …
for the production of the amyloid-β (Aβ) peptide, which is central to the pathogenesis of …
Requirement for hippocampal CA3 NMDA receptors in associative memory recall
Pattern completion, the ability to retrieve complete memories on the basis of incomplete sets
of cues, is a crucial function of biological memory systems. The extensive recurrent …
of cues, is a crucial function of biological memory systems. The extensive recurrent …
Surface melt-induced acceleration of Greenland ice-sheet flow
Ice flow at a location in the equilibrium zone of the west-central Greenland Ice Sheet
accelerates above the midwinter average rate during periods of summer melting. The near …
accelerates above the midwinter average rate during periods of summer melting. The near …
Distinct pattern separation related transfer functions in human CA3/dentate and CA1 revealed using high-resolution fMRI and variable mnemonic similarity
Producing and maintaining distinct (orthogonal) neural representations for similar events is
critical to avoiding interference in long-term memory. Recently, our laboratory provided the …
critical to avoiding interference in long-term memory. Recently, our laboratory provided the …
Single granule cells reliably discharge targets in the hippocampal CA3 network in vivo
Processing of neuronal information depends on interactions between the anatomical
connectivity and cellular properties of single cells. We examined how these computational …
connectivity and cellular properties of single cells. We examined how these computational …
The CA3 “backprojection” to the dentate gyrus
HE Scharfman - Progress in brain research, 2007 - Elsevier
The hippocampus is typically described in the context of the trisynaptic circuit, a pathway that
relays information from the perforant path to the dentate gyrus, dentate to area CA3, and …
relays information from the perforant path to the dentate gyrus, dentate to area CA3, and …
Paradox of pattern separation and adult neurogenesis: A dual role for new neurons balancing memory resolution and robustness
ST Johnston, M Shtrahman, S Parylak… - Neurobiology of learning …, 2016 - Elsevier
Hippocampal adult neurogenesis is thought to subserve pattern separation, the process by
which similar patterns of neuronal inputs are transformed into distinct neuronal …
which similar patterns of neuronal inputs are transformed into distinct neuronal …
The CRISP theory of hippocampal function in episodic memory
S Cheng - Frontiers in neural circuits, 2013 - frontiersin.org
Over the past four decades, a “standard framework” has emerged to explain the neural
mechanisms of episodic memory storage. This framework has been instrumental in driving …
mechanisms of episodic memory storage. This framework has been instrumental in driving …
Plasticity-dependent, full detonation at hippocampal mossy fiber–CA3 pyramidal neuron synapses
Mossy fiber synapses on CA3 pyramidal cells are'conditional detonators' that reliably
discharge postsynaptic targets. The'conditional'nature implies that burst activity in dentate …
discharge postsynaptic targets. The'conditional'nature implies that burst activity in dentate …