Background: Effective targeting of services requires that we establish which undergraduates
are at increased risk of mental health problems at university. We aimed to conduct a …

Frailty is a complex age-related clinical condition characterised by a decline in physiological
capacity across several organ systems, with a resultant increased susceptibility to stressors …

Prediction models in health care use predictors to estimate for an individual the probability
that a condition or disease is already present (diagnostic model) or will occur in the future …

Prognostic factors are associated with the risk of future health outcomes in individuals with a
particular health condition or some clinical start point (eg, a particular diagnosis). Research …

Drug discovery and development affects various aspects of human health and dramatically
impacts the pharmaceutical market. However, investments in a new drug often go …

Heterogeneity of treatment effect (HTE) refers to the nonrandom variation in the magnitude
or direction of a treatment effect across levels of a covariate, as measured on a selected …

Importance Depression is a major cause of disability worldwide. Although empirically
supported treatments are available, there is scarce evidence on how to effectively …

The term “precision medicine” has become very popular over recent years, fuelled by
scientific as well as political perspectives. Despite its popularity, its exact meaning, and how …

The use of evidence from clinical trials to support decisions for individual patients is a form of
“reference class forecasting”: implicit predictions for an individual are made on the basis of …

Mental health researchers and clinicians have long sought answers to the question “What
works for whom?” The goal of precision medicine is to provide evidence-based answers to …