Although estrogen is predominantly related to the maintenance of reproductive functioning
in females, it mediates various physiological effects in nearly all tissues, especially the …

Carriers of BRCA1 mutations have a higher chance of develo** cancers in hormone-
responsive tissues like the breast, ovary and prostate, compared to other tissues. These …

The non-coding RNA (ncRNA) regulation appears to be associated to the diagnosis and
targeted therapy of complex diseases. Motifs of non-coding RNAs and genes in the …

Improving the efficacy of anticancer drugs is especially challenging. Estrogen is a sex
hormone that not only promotes the development of female secondary sexual …

Platinum drug-based chemotherapy plays a dominant role in OC (ovarian cancer) treatment.
The expression of DNA damage repair (DDR) genes is critical in distinguishing drug …

High-grade serous ovarian cancer (HGSOC) has abundant expression of hormone
receptors, including androgen receptor (AR), estrogen receptor α (ER), and progesterone …

Over the last few decades, the incidence of urogenital cancers has exhibited diverse trends
influenced by screening programs and geographical variations. Among women, there has …

The estrogen receptor alpha (ESR1) is an important gene transcriptional regulator, known to
mediate the effects of estrogen. Canonically, ESR1 is activated by its ligand estrogen …

Background Cancer cells may develop resistance to cisplatin by various mechanisms. Yet,
the exact mechanism of cisplatin in ovarian cancer remains unclear. Recent studies have …

Purpose Ultrasound-mediated nanobubbles destruction (UTND) technology could enhance
drug transport efficiency and increase the local drug concentration. We structured a novel …