Inflammation and immunity in schizophrenia: implications for pathophysiology and treatment

GM Khandaker, L Cousins, J Deakin… - The Lancet …, 2015 - thelancet.com
Complex interactions between the immune system and the brain might have important
aetiological and therapeutic implications for neuropsychiatric brain disorders. A possible …

Maternal immune activation and abnormal brain development across CNS disorders

I Knuesel, L Chicha, M Britschgi, SA Schobel… - Nature Reviews …, 2014 - nature.com
Epidemiological studies have shown a clear association between maternal infection and
schizophrenia or autism in the progeny. Animal models have revealed maternal immune …

Environmental risk factors for schizophrenia and bipolar disorder and their relationship to genetic risk: current knowledge and future directions

N Robinson, SE Bergen - Frontiers in genetics, 2021 - frontiersin.org
Schizophrenia (SZ) and bipolar disorder (BD) are severe psychiatric disorders which result
from complex interplay between genetic and environmental factors. It is well-established that …

Maternal immune activation and neuropsychiatric illness: a translational research perspective

AS Brown, U Meyer - American Journal of Psychiatry, 2018 - Am Psychiatric Assoc
Epidemiologic studies, including prospective birth cohort investigations, have implicated
maternal immune activation in the etiology of neuropsychiatric disorders. Maternal infectious …

Preterm birth and sustained inflammation: consequences for the neonate

A Humberg, I Fortmann, B Siller, MV Kopp… - Seminars in …, 2020 - Springer
Almost half of all preterm births are caused or triggered by an inflammatory process at the
feto-maternal interface resulting in preterm labor or rupture of membranes with or without …

[HTML][HTML] Brain changes in a maternal immune activation model of neurodevelopmental brain disorders

L Bergdolt, A Dunaevsky - Progress in neurobiology, 2019 - Elsevier
The develo** brain is sensitive to a variety of insults. Epidemiological studies have
identified prenatal exposure to infection as a risk factor for a range of neurological disorders …

Prenatal poly (i: C) exposure and other developmental immune activation models in rodent systems

U Meyer - Biological psychiatry, 2014 - Elsevier
It is increasingly appreciated that altered neuroimmune mechanisms might play a role in the
development of schizophrenia and related psychotic illnesses. On the basis of human …

Neurodevelopmental resilience and susceptibility to maternal immune activation

U Meyer - Trends in neurosciences, 2019 - cell.com
Maternal immune activation (MIA), be it triggered by infectious or noninfectious stimuli, is
implicated in various psychiatric and neurological disorders with developmental etiologies …

Maternal immune activation by poly I: C as a preclinical model for neurodevelopmental disorders: a focus on autism and schizophrenia

FL Haddad, SV Patel, S Schmid - Neuroscience & Biobehavioral Reviews, 2020 - Elsevier
Maternal immune activation (MIA) in response to a viral infection during early and mid-
gestation has been linked through various epidemiological studies to a higher risk for the …

The environment and susceptibility to schizophrenia

AS Brown - Progress in neurobiology, 2011 - Elsevier
In the present article the putative role of environmental factors in schizophrenia is reviewed
and synthesized. Accumulating evidence from recent studies suggests that environmental …