Synaptic plasticity and mental health: methods, challenges and opportunities

LG Appelbaum, MA Shenasa, L Stolz… - …, 2023‏ - nature.com
Activity-dependent synaptic plasticity is a ubiquitous property of the nervous system that
allows neurons to communicate and change their connections as a function of past …

Neurobiology of early life adversity: A systematic review of meta-analyses towards an integrative account of its neurobiological trajectories to mental disorders

Y Hakamata, Y Suzuki, H Kobashikawa… - Frontiers in …, 2022‏ - Elsevier
Adverse childhood experiences (ACEs) may leave long-lasting neurobiological scars,
increasing the risk of develo** mental disorders in later life. However, no review has …

Lower synaptic density is associated with depression severity and network alterations

SE Holmes, D Scheinost, SJ Finnema… - Nature …, 2019‏ - nature.com
Synaptic loss and deficits in functional connectivity are hypothesized to contribute to
symptoms associated with major depressive disorder (MDD) and post-traumatic stress …

Inflammation and post‐traumatic stress disorder

H Hori, Y Kim - Psychiatry and clinical neurosciences, 2019‏ - Wiley Online Library
While post‐traumatic stress disorder (PTSD) is currently diagnosed based solely on classic
psychological and behavioral symptoms, a growing body of evidence has highlighted a link …

Psychedelics and other psychoplastogens for treating mental illness

MV Vargas, R Meyer, AA Avanes, M Rus… - Frontiers in …, 2021‏ - frontiersin.org
Psychedelics have inspired new hope for treating brain disorders, as they seem to be unlike
any treatments currently available. Not only do they produce sustained therapeutic effects …

The temporal pole: From anatomy to function—A literature appraisal

B Herlin, V Navarro, S Dupont - Journal of chemical neuroanatomy, 2021‏ - Elsevier
Historically, the anterior part of the temporal lobe was labelled as a unique structure named
Brain Area 38 by Brodmann or Temporopolar Area TG by Von Economo, but its functions …

Identification of a common neurobiological substrate for mental illness

M Goodkind, SB Eickhoff, DJ Oathes, Y Jiang… - JAMA …, 2015‏ - jamanetwork.com
Importance Psychiatric diagnoses are currently distinguished based on sets of specific
symptoms. However, genetic and clinical analyses find similarities across a wide variety of …

Inflammatory markers in post-traumatic stress disorder: a systematic review, meta-analysis, and meta-regression

IC Passos, MP Vasconcelos-Moreno, LG Costa… - The Lancet …, 2015‏ - thelancet.com
Background Studies investigating inflammatory markers in post-traumatic stress disorder
(PTSD) have yielded mixed results. The aim of our study was to compare concentrations of …

Stress weakens prefrontal networks: molecular insults to higher cognition

AFT Arnsten - Nature neuroscience, 2015‏ - nature.com
A variety of cognitive disorders are worsened by stress exposure and involve dysfunction of
the newly evolved prefrontal cortex (PFC). Exposure to acute, uncontrollable stress …

Biochemical mechanisms underlying psychedelic-induced neuroplasticity

DE Olson - Biochemistry, 2022‏ - ACS Publications
In addition to producing profound subjective effects following acute administration,
psychedelic compounds can induce beneficial behavioral changes relevant to the treatment …