The survival of insects depends on their ability to detect molecules present in their
environment. Odorant-binding proteins (OBPs) form a family of proteins involved in …

The majority of insect olfactory receptors belong to two distinct protein families, the
ionotropic receptors (IRs), which are related to the ionotropic glutamate receptor family, and …

Olfactory systems must detect and discriminate amongst an enormous variety of odorants.
To contend with this challenge, diverse species have converged on a common strategy in …

Despite decades of work by structural biologists, there are still~ 5200 protein families with
unknown structure outside the range of comparative modeling. We show that Rosetta …

The olfactory system must recognize and discriminate amongst an enormous variety of
chemicals in the environment. To contend with such diversity, insects have evolved a family …

The evolutionary origins of the three major families of chemoreceptors in arthropods—the
odorant receptor (OR), gustatory receptor (GR), and ionotropic receptor (IR) families …

Chemoreception is essential for survival. Feeding, mating, and avoidance of predators
depend on detection of sensory cues. Drosophila contains diverse families of …

Recently, two alternative targets in insect periphery nerve system have been explored for
environmentally-friendly approaches in insect pest management, namely odorant-binding …

Engineering proteins and enzymes with the desired functionality has broad applications in
molecular biology, biotechnology, biomedical sciences, health, and medicine. The vastness …

The prediction of the structures of proteins without detectable sequence similarity to any
protein of known structure remains an outstanding scientific challenge. Here we report …