Aurora kinases are serine/threonine kinases essential for the onset and progression of
mitosis. Aurora members share a similar protein structure and kinase activity, but exhibit …

Mitosis and meiosis are remarkable processes during which cells undergo profound
changes in their structure and physiology. These events are orchestrated with a precision …

Large numbers of inhibitors for polo-like kinases and aurora kinases are currently being
evaluated as anticancer drugs. Interest in these drugs is fuelled by the idea that these …

The Aurora kinases, which include Aurora A (AURKA), Aurora B (AURKB) and Aurora C
(AURKC), are serine/threonine kinases required for the control of mitosis (AURKA and …

BACKGROUND Male infertility affects> 20 million men worldwide and represents a major
health concern. Although multifactorial, male infertility has a strong genetic basis which has …

The gene encoding the Aurora-A protein kinase is located in the 20q13 breast cancer
amplicon and is also overexpressed in colorectal, pancreatic and gastric tumours. Although …

The Aurora protein kinase family (consisting of Aurora-A,-B and-C) is an important group of
enzymes that controls several aspects of cell division in mammalian cells. Dysfunction of …

The conserved Aurora family of protein kinases have emerged as crucial regulators of
mitosis and cytokinesis. Despite their high degree of homology, Aurora A and B have very …

Spermatogenesis, a study of germ cell development, is a long, orderly, and well‐defined
process occurring in seminiferous tubules of the testis. It is a temporal event whereby …

Mechanisms regulating mammalian meiotic progression are poorly understood. Here we
identify mouse YTHDC2 as a critical component. A screen yielded a sterile mutant,'ketu' …