The complement system is an ancient collection of proteolytic cascades with well-described
roles in regulation of innate and adaptive immunity. With the convergence of a revolution in …

Epilepsy is one of most common chronic neurological disorders, and the antiseizure
medications developed by targeting neurocentric mechanisms have not effectively reduced …

Alzheimer's disease (AD) is characterized by synaptic loss, which can result from
dysfunctional microglial phagocytosis and complement activation. However, what signals …

Huntington's disease (HD) is a devastating monogenic neurodegenerative disease
characterized by early, selective pathology in the basal ganglia despite the ubiquitous …

Sepsis-associated encephalopathy (SAE) is a severe and frequent complication of sepsis
causing delirium, coma, and long-term cognitive dysfunction. We identified microglia and …

A large set of inflammatory molecules and their receptors are induced in epileptogenic foci
of patients with pharmacoresistant epilepsies of structural etiologies or with refractory status …

Epilepsy is a major disorder affecting millions of people. Although modern
electrophysiological and imaging approaches provide high-resolution access to the multi …

General anesthesia (GA) is an unconscious state produced by anesthetic drugs, which act
on neurons to cause overall suppression of neuronal activity in the brain. Recent studies …

Alzheimer's disease (AD) is the leading cause of dementia in older adults, and the need for
effective, sustainable therapeutic targets is imperative. The complement pathway has been …

C1q is a crucial component of the complement system, which is activated through the
classical pathway to perform non-specific immune functions, serving as the first line of …