Deep learning-enabled virtual histological staining of biological samples

B Bai, X Yang, Y Li, Y Zhang, N Pillar… - Light: Science & …, 2023 - nature.com
Histological staining is the gold standard for tissue examination in clinical pathology and life-
science research, which visualizes the tissue and cellular structures using chromatic dyes or …

Roadmap on label‐free super‐resolution imaging

VN Astratov, YB Sahel, YC Eldar… - Laser & photonics …, 2023 - Wiley Online Library
Label‐free super‐resolution (LFSR) imaging relies on light‐scattering processes in
nanoscale objects without a need for fluorescent (FL) staining required in super‐resolved FL …

Noninvasive virtual biopsy using micro-registered optical coherence tomography (OCT) in human subjects

Y Winetraub, A Van Vleck, E Yuan, I Terem, J Zhao… - Science …, 2024 - science.org
Histological hematoxylin and eosin–stained (H&E) tissue sections are used as the gold
standard for pathologic detection of cancer, tumor margin detection, and disease diagnosis …

Accelerating histopathology workflows with generative AI-based virtually multiplexed tumour profiling

P Pati, S Karkampouna, F Bonollo… - Nature machine …, 2024 - nature.com
Understanding the spatial heterogeneity of tumours and its links to disease initiation and
progression is a cornerstone of cancer biology. Presently, histopathology workflows heavily …

Quantitative phase imaging through an ultra-thin lensless fiber endoscope

J Sun, J Wu, S Wu, R Goswami, S Girardo… - Light: Science & …, 2022 - nature.com
Quantitative phase imaging (QPI) is a label-free technique providing both morphology and
quantitative biophysical information in biomedicine. However, applying such a powerful …

Skin cancer pathobiology at a glance: a focus on imaging techniques and their potential for improved diagnosis and surveillance in clinical cohorts

EG Dobre, M Surcel, C Constantin, MA Ilie… - International Journal of …, 2023 - mdpi.com
Early diagnosis is essential for completely eradicating skin cancer and maximizing patients'
clinical benefits. Emerging optical imaging modalities such as reflectance confocal …

Virtual histological staining of unlabeled autopsy tissue

Y Li, N Pillar, J Li, T Liu, D Wu, S Sun, G Ma… - Nature …, 2024 - nature.com
Traditional histochemical staining of post-mortem samples often confronts inferior staining
quality due to autolysis caused by delayed fixation of cadaver tissue, and such chemical …

[HTML][HTML] Label-free virtual HER2 immunohistochemical staining of breast tissue using deep learning

B DoanNgan, DM Angus, LH Sung - BME frontiers, 2022 - spj.science.org
The immunohistochemical (IHC) staining of the human epidermal growth factor receptor 2
(HER2) biomarker is widely practiced in breast tissue analysis, preclinical studies, and …

Label-and slide-free tissue histology using 3D epi-mode quantitative phase imaging and virtual hematoxylin and eosin staining

TM Abraham, PC Costa, C Filan, Z Guang, Z Zhang… - Optica, 2023 - opg.optica.org
Histological staining of tissue biopsies, especially hematoxylin and eosin (H&E) staining,
serves as the benchmark for disease diagnosis and comprehensive clinical assessment of …

At the intersection of optics and deep learning: statistical inference, computing, and inverse design

D Mengu, MS Sakib Rahman, Y Luo, J Li… - Advances in Optics …, 2022 - opg.optica.org
Deep learning has been revolutionizing information processing in many fields of science
and engineering owing to the massively growing amounts of data and the advances in deep …