A systematic review of multimodal brain age studies: Uncovering a divergence between model accuracy and utility

RJ Jirsaraie, AJ Gorelik, MM Gatavins, DA Engemann… - Patterns, 2023 - cell.com
Brain aging is a complex, multifaceted process that can be challenging to model in ways that
are accurate and clinically useful. One of the most common approaches has been to apply …

[HTML][HTML] A review of the pathology and treatment of TBI and PTSD

M Monsour, D Ebedes, CV Borlongan - Experimental neurology, 2022 - Elsevier
This literature review focuses on the underlying pathophysiology of TBI and PTSD
symptoms, while also examining the plethora of stem cell treatment options to ameliorate …

Sex-based contributors to and consequences of post-traumatic stress disorder

LV Hiscox, TH Sharp, M Olff, S Seedat… - Current Psychiatry …, 2023 - Springer
Abstract Purpose of Review Women are twice as likely to develop post-traumatic stress
disorder (PTSD) compared to men after a traumatic experience. The purpose of this mini …

Brain age prediction using combined deep convolutional neural network and multi-layer perceptron algorithms

Y Joo, E Namgung, H Jeong, I Kang, J Kim, S Oh… - Scientific Reports, 2023 - nature.com
The clinical applications of brain age prediction have expanded, particularly in anticipating
the onset and prognosis of various neurodegenerative diseases. In the current study, we …

Life course, genetic, and neuropathological associations with brain age in the 1946 British Birth Cohort: a population-based study

AZ Wagen, W Coath, A Keshavan… - The Lancet Healthy …, 2022 - thelancet.com
Background A neuroimaging-based biomarker termed the brain age is thought to reflect
variability in the brain's ageing process and predict longevity. Using Insight 46, a unique …

[HTML][HTML] Brain-age is associated with progression to dementia in memory clinic patients

F Biondo, A Jewell, M Pritchard, D Aarsland… - NeuroImage: Clinical, 2022 - Elsevier
Background Biomarkers for the early detection of dementia risk hold promise for better
disease monitoring and targeted interventions. However, most biomarker studies …

Association of maternal depression during pregnancy and recent stress with brain age among adult offspring

K Mareckova, R Mareček, M Jani, L Zackova… - JAMA Network …, 2023 - jamanetwork.com
Importance Maternal mental health problems during pregnancy are associated with altered
neurodevelopment in offspring, but the long-term relationship between these prenatal risk …

[HTML][HTML] Advanced brain ageing in adult psychopathology: A systematic review and meta-analysis of structural MRI studies

KV Blake, Z Ntwatwa, T Kaufmann, DJ Stein… - Journal of psychiatric …, 2023 - Elsevier
Evidence suggests that psychopathology is associated with an advanced brain ageing
process, typically mapped using machine learning models that predict an individual's age …

Advanced brain-age in psychotic psychopathology: evidence for transdiagnostic neurodevelopmental origins

C Demro, C Shen, TJ Hendrickson, JL Arend… - Frontiers in aging …, 2022 - frontiersin.org
Schizophrenia is characterized by abnormal brain structure such as global reductions in
gray matter volume. Machine learning models trained to estimate the age of brains from …

Epigenetic aging mediates the association between pain impact and brain aging in middle to older age individuals with knee pain

JA Peterson, LJ Strath, CL Nodarse, A Rani, Z Huo… - Epigenetics, 2022 - Taylor & Francis
Chronic musculoskeletal pain is a health burden that may accelerate the aging process.
Accelerated brain aging and epigenetic aging have separately been observed in those with …