The spatial separation of protein synthesis from the compartmental destiny of proteins led to
the evolution of transport systems that are efficient and yet highly specific. Co-translational …

Nucleoporins (nups) in the nuclear pore complex (NPC) form a selective barrier that
suppresses the diffusion of most macromolecules while enabling rapid transport of nuclear …

Changing environmental conditions necessitate rapid adaptation of cytoplasmic and nuclear
volumes. We use the slime mold Dictyostelium discoideum, known for its ability to tolerate …

Nuclear pore complexes (NPCs) are giant molecular assemblies that form the gateway
between the nucleus and the cytoplasm and accommodate the bidirectional transport of a …

Single-molecule fluorescence imaging experiments generally require sub-nanomolar
protein concentrations to isolate single protein molecules, which makes such experiments …

Activating the cGAS-STING pathway presents a promising strategy to enhance the innate
immunity and combat the immunosuppressive tumor microenvironment. One key …

Abstract The Nuclear Pore Complex (NPC) facilitates rapid and selective nucleocytoplasmic
transport of molecules as large as ribosomal subunits and viral capsids. It is not clear how …

Nuclear pore complexes (NPCs) play a critical role in regulating transport-dependent gene
expression, influencing various stages of cancer development and progression …

Cell-type specific and environmentally-responsive plasticity in nuclear pore complex (NPC)
composition and structure is an emerging area of investigation, but its molecular …