The increasing frequency of nosocomial infections due to multi-resistant pathogens exerts a
significant toll and calls for novel and better antibiotics. Different approaches can be used in …

Cells employ many mechanisms to ensure quality control during protein biosynthesis. Here,
we show that, during the pausing of a bacterial ribosome, the mRNA being translated is …

Aminoglycoside-class antibiotics bind directly to ribosomal RNA, imparting pleiotropic effects
on ribosome function. Despite in-depth structural investigations of aminoglycoside–RNA …

2-Deoxystreptamine (2-DOS) aminoglycoside antibiotics bind specifically to the central
region of the 16S rRNA A site and interfere with protein synthesis. Recently, we have shown …

Trans-translation is a process found in all bacteria, which contributes to the release of
ribosomes that are stalled through a variety of causes, for example when the 3′ end of a …

Dynamic remodelling of intersubunit bridge B2, a conserved RNA domain of the bacterial
ribosome connecting helices 44 (h44) and 69 (H69) of the small and large subunit …

The chaperone homologs RAC (ribosome-associated complex) and Ssb1/2p are anchored
to ribosomes; Ssb1/2p directly interacts with nascent polypeptides. The absence of RAC or …

Background: We have shown recently that read‐through of a normal stop codon by a
suppressor tRNA in specific genes possessing a Rho‐independent terminator leads to SsrA …

Contents EI Christensen and R. Nielsen: Role of Megalin and Cubilin in Renal Physiology
and Pathophysiology G. Zifarelli and M. Pusch: CLC Chloride Channels and Transporters: A …

A robust analysis and discovery platform for antibiotics targeting the bacterial rRNA A-site
has been developed by incorporating a new emissive U surrogate into the RNA and labeling …