Chromosomal instability (CIN) is a hallmark of cancer and is associated with tumor cell
malignancy. CIN triggers a chain reaction in cells leading to chromosomal abnormalities …

Cancer is a dynamic disease. During the course of disease, cancers generally become more
heterogeneous. As a result of this heterogeneity, the bulk tumour might include a diverse …

Aneuploidy, whole chromosome or chromosome arm imbalance, is a near-universal
characteristic of human cancers. In 10,522 cancer genomes from The Cancer Genome Atlas …

INTRODUCTION Aneuploidy, also known as somatic copy number alterations (SCNAs), is
widespread in human cancers and has been proposed to drive tumorigenesis. The …

Accessing the natural genetic diversity of species unveils hidden genetic traits, clarifies gene
functions and allows the generalizability of laboratory findings to be assessed. One notable …

Aneuploidies—whole-chromosome or whole-arm imbalances—are the most prevalent
alteration in cancer genomes,. However, it is still debated whether their prevalence is due to …

Innate lymphoid cells (ILCs) are innate counterparts of adaptive T lymphocytes, contributing
to host defense, tissue repair, metabolic homeostasis, and inflammatory diseases. ILCs have …

Aberrant chromosomal architecture, ranging from small insertions or deletions to large
chromosomal alterations, is one of the most common characteristics of cancer genomes …

Genoty** tumor tissue in search of somatic genetic alterations for actionable information
has become routine practice in clinical oncology. Although these sequence alterations are …

The centromere is the region of the chromosome that directs its segregation in mitosis and
meiosis. Although the functional importance of the centromere has been appreciated for …