Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

Background The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad
pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose …

Diabetes mellitus (DM) is a highly prevalent disease worldwide, estimated to affect 1 in
every 11 adults; among them, 90–95% of cases are type 2 diabetes mellitus. This is partly …

Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy
homeostasis, many exciting insights into its structure, regulation and physiological roles …

Antipsychotic drugs are central to the treatment of schizophrenia and other psychotic
disorders but are ineffective for some patients and associated with side-effects and …

Complex multicellular organisms require a coordinated response from multiple tissues to
maintain whole-body homeostasis in the face of energetic stressors such as fasting, cold …

Obesity is a major health crisis affecting over a third of the global population. This
multifactorial disease is regulated via interoceptive neural circuits in the brain, whose …

Stimulation of adipose tissue thermogenesis is regarded as a promising avenue in the
treatment of obesity. However, pharmacologic engagement of this process has proven …

During the past 30 yr, investigating the physiology of eating behaviors has generated a truly
vast literature. This is fueled in part by a dramatic increase in obesity and its comorbidities …

Background Insulin resistance (IR) is one of the major hallmark for pathogenesis and
etiology of type 2 diabetes mellitus (T2DM). IR is directly interlinked with various …