The Wnt signaling pathway in cancer
Y Duchartre, YM Kim, M Kahn - Critical reviews in oncology/hematology, 2016 - Elsevier
The Wnt signaling pathway is critically involved in both the development and homeostasis of
tissues via regulation of their endogenous stem cells. Aberrant Wnt signaling has been …
tissues via regulation of their endogenous stem cells. Aberrant Wnt signaling has been …
[HTML][HTML] Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health
WH Chappell, LS Steelman, JM Long, RC Kempf… - Oncotarget, 2011 - ncbi.nlm.nih.gov
Abstract The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by
genetic alterations in upstream signaling molecules such as receptor tyrosine kinases …
genetic alterations in upstream signaling molecules such as receptor tyrosine kinases …
Wnt/catenin signaling in adult stem cell physiology and disease
Wnt signaling plays an important role in development and disease. In this review we focus
on the role of the canonical Wnt signaling pathway in somatic stem cell biology and its …
on the role of the canonical Wnt signaling pathway in somatic stem cell biology and its …
Breast-cancer stem cells—beyond semantics
Intratumoral heterogeneity in breast cancer is well documented. Although the mechanisms
leading to this heterogeneity are not understood, a subpopulation of cancer cells, cancer …
leading to this heterogeneity are not understood, a subpopulation of cancer cells, cancer …
Breast cancer stem cells: treatment resistance and therapeutic opportunities
F Al-Ejeh, CE Smart, BJ Morrison… - …, 2011 - academic.oup.com
The clinical and pathologic heterogeneity of human breast cancer has long been
recognized. Now, molecular profiling has enriched our understanding of breast cancer …
recognized. Now, molecular profiling has enriched our understanding of breast cancer …
The role of the Wnt signaling pathway in cancer stem cells: prospects for drug development
YM Kim, M Kahn - Research and reports in biochemistry, 2014 - Taylor & Francis
Cancer stem cells (CSCs), also known as tumor initiating cells are now considered to be the
root cause of most if not all cancers, evading treatment and giving rise to disease relapse …
root cause of most if not all cancers, evading treatment and giving rise to disease relapse …
Dynamic regulation of mitochondrial-endoplasmic reticulum crosstalk during stem cell homeostasis and aging
Cellular therapy exerts profound therapeutic potential for curing a broad spectrum of
diseases. Adult stem cells reside within a specified dynamic niche in vivo, which is essential …
diseases. Adult stem cells reside within a specified dynamic niche in vivo, which is essential …
PKM2 promotes stemness of breast cancer cell by through Wnt/β-catenin pathway
Z Zhao, Z Song, Z Liao, Z Liu, H Sun, B Lei, W Chen… - Tumor Biology, 2016 - Springer
Metastasis is one of the main causes of breast cancer (BCa)-related deaths in female. It has
been reported that cancer stem cell played an important role in metastasis. Here we first …
been reported that cancer stem cell played an important role in metastasis. Here we first …
BRAF, p53 and SOX2 in anaplastic thyroid carcinoma: evidence for multistep carcinogenesis
Aims The aim of this study was to genotype a series of papillary thyroid carcinomas (PTCs)
and anaplastic thyroid carcinomas (ATCs) for BRAF mutation, and to evaluate p53 and …
and anaplastic thyroid carcinomas (ATCs) for BRAF mutation, and to evaluate p53 and …
Effect of low dose bisphenol A on the early differentiation of human embryonic stem cells into mammary epithelial cells
L Yang, L Luo, W Ji, C Gong, D Wu, H Huang, Q Liu… - Toxicology letters, 2013 - Elsevier
It has been previously reported that Bisphenol A (BPA) can disturb the development of
mammary structure and increase the risk of breast cancer in experimental animals. In this …
mammary structure and increase the risk of breast cancer in experimental animals. In this …