[PDF][PDF] ISPAD Clinical Practice Consensus Guidelines 2022: Stages of type 1 diabetes in children and adolescents.
ISPAD clinical practice consensus guidelines 2022: Stages of type 1 diabetes in children and
adolescents Page 1 ISPAD GUIDELINES ISPAD clinical practice consensus guidelines 2022 …
adolescents Page 1 ISPAD GUIDELINES ISPAD clinical practice consensus guidelines 2022 …
Towards clinical utility of polygenic risk scores
Prediction of disease risk is an essential part of preventative medicine, often guiding clinical
management. Risk prediction typically includes risk factors such as age, sex, family history of …
management. Risk prediction typically includes risk factors such as age, sex, family history of …
The heterogeneous pathogenesis of type 1 diabetes mellitus
J Ilonen, J Lempainen, R Veijola - Nature Reviews Endocrinology, 2019 - nature.com
Type 1 diabetes mellitus (T1DM) results from the destruction of pancreatic β-cells that is
mediated by the immune system. Multiple genetic and environmental factors found in …
mediated by the immune system. Multiple genetic and environmental factors found in …
The clinical consequences of heterogeneity within and between different diabetes types
Advances in molecular methods and the ability to share large population-based datasets are
uncovering heterogeneity within diabetes types, and some commonalities between types …
uncovering heterogeneity within diabetes types, and some commonalities between types …
Diagnosis and treatment of type 1 diabetes at the dawn of the personalized medicine era
Type 1 diabetes affects millions of people globally and requires careful management to
avoid serious long-term complications, including heart and kidney disease, stroke, and loss …
avoid serious long-term complications, including heart and kidney disease, stroke, and loss …
Introducing the endotype concept to address the challenge of disease heterogeneity in type 1 diabetes
M Battaglia, S Ahmed, MS Anderson… - Diabetes …, 2020 - Am Diabetes Assoc
The clinical diagnosis of new-onset type 1 diabetes has, for many years, been considered
relatively straightforward. Recently, however, there is increasing awareness that within this …
relatively straightforward. Recently, however, there is increasing awareness that within this …
Heterogeneity and endotypes in type 1 diabetes mellitus
Despite major advances over the past decade, prevention and treatment of type 1 diabetes
mellitus (T1DM) remain suboptimal, with large and unexplained variations in individual …
mellitus (T1DM) remain suboptimal, with large and unexplained variations in individual …
Development and standardization of an improved type 1 diabetes genetic risk score for use in newborn screening and incident diagnosis
OBJECTIVE Previously generated genetic risk scores (GRSs) for type 1 diabetes (T1D) have
not captured all known information at non-HLA loci or, particularly, at HLA risk loci. We …
not captured all known information at non-HLA loci or, particularly, at HLA risk loci. We …
Treatment strategies against diabetes: Success so far and challenges ahead
The growing disease burden of diabetes mellitus is an important public health concern,
affecting over 400 million people globally. This epidemic, if not controlled in time, leads to …
affecting over 400 million people globally. This epidemic, if not controlled in time, leads to …
A combined risk score enhances prediction of type 1 diabetes among susceptible children
Abstract Type 1 diabetes (T1D)—an autoimmune disease that destroys the pancreatic islets,
resulting in insulin deficiency—often begins early in life when islet autoantibody appearance …
resulting in insulin deficiency—often begins early in life when islet autoantibody appearance …