Minimum information about a single amplified genome (MISAG) and a metagenome-assembled genome (MIMAG) of bacteria and archaea

RM Bowers, NC Kyrpides, R Stepanauskas… - Nature …, 2017 - nature.com
We present two standards developed by the Genomic Standards Consortium (GSC) for
reporting bacterial and archaeal genome sequences. Both are extensions of the Minimum …

The human gut microbiome: from association to modulation

TSB Schmidt, J Raes, P Bork - Cell, 2018 - cell.com
Our understanding of the human gut microbiome continues to evolve at a rapid pace, but
practical application of thisknowledge is still in its infancy. This review discusses the type of …

Unravelling the collateral damage of antibiotics on gut bacteria

L Maier, CV Goemans, J Wirbel, M Kuhn, C Eberl… - Nature, 2021 - nature.com
Antibiotics are used to fight pathogens but also target commensal bacteria, disturbing the
composition of gut microbiota and causing dysbiosis and disease. Despite this well-known …

Combinatorial, additive and dose-dependent drug–microbiome associations

SK Forslund, R Chakaroun… - Nature, 2021 - nature.com
During the transition from a healthy state to cardiometabolic disease, patients become
heavily medicated, which leads to an increasingly aberrant gut microbiome and serum …

Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer

S Yachida, S Mizutani, H Shiroma, S Shiba… - Nature medicine, 2019 - nature.com
In most cases of sporadic colorectal cancers, tumorigenesis is a multistep process, involving
genomic alterations in parallel with morphologic changes. In addition, accumulating …

Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer

J Wirbel, PT Pyl, E Kartal, K Zych, A Kashani… - Nature medicine, 2019 - nature.com
Association studies have linked microbiome alterations with many human diseases.
However, they have not always reported consistent results, thereby necessitating cross …

[HTML][HTML] Biosynthetic potential of the global ocean microbiome

L Paoli, HJ Ruscheweyh, CC Forneris, F Hubrich… - Nature, 2022 - nature.com
Natural microbial communities are phylogenetically and metabolically diverse. In addition to
underexplored organismal groups, this diversity encompasses a rich discovery potential for …

Species-level functional profiling of metagenomes and metatranscriptomes

EA Franzosa, LJ McIver, G Rahnavard, LR Thompson… - Nature …, 2018 - nature.com
Functional profiles of microbial communities are typically generated using comprehensive
metagenomic or metatranscriptomic sequence read searches, which are time-consuming …

NetCoMi: network construction and comparison for microbiome data in R

S Peschel, CL Müller, E Von Mutius… - Briefings in …, 2021 - academic.oup.com
Motivation Estimating microbial association networks from high-throughput sequencing data
is a common exploratory data analysis approach aiming at understanding the complex …

New insights from uncultivated genomes of the global human gut microbiome

S Nayfach, ZJ Shi, R Seshadri, KS Pollard… - Nature, 2019 - nature.com
The genome sequences of many species of the human gut microbiome remain unknown,
largely owing to challenges in cultivating microorganisms under laboratory conditions. Here …