Recent advance on carbamate-based cholinesterase inhibitors as potential multifunctional agents against Alzheimer's disease

H Zhang, Y Wang, Y Wang, X Li, S Wang… - European Journal of …, 2022 - Elsevier
Abstract Alzheimer's disease (AD), as the fourth leading cause of death among the elderly
worldwide, has brought enormous challenge to the society. Due to its extremely complex …

Glutamate and GABA in microglia-neuron cross-talk in Alzheimer's disease

GA Czapski, JB Strosznajder - International Journal of Molecular Sciences, 2021 - mdpi.com
The physiological balance between excitation and inhibition in the brain is significantly
affected in Alzheimer's disease (AD). Several neuroactive compounds and their signaling …

Exposure to environmental arsenic and emerging risk of Alzheimer's disease: perspective mechanisms, management strategy, and future directions

MA Rahman, MA Hannan, MJ Uddin, MS Rahman… - Toxics, 2021 - mdpi.com
Alzheimer's disease (AD) is one of the most prevailing neurodegenerative diseases,
characterized by memory dysfunction and the presence of hyperphosphorylated tau and …

Modulatory effects of autophagy on APP processing as a potential treatment target for Alzheimer's disease

MA Rahman, MS Rahman, MDH Rahman… - Biomedicines, 2020 - mdpi.com
Alzheimer's disease (AD) is characterized by the formation of intracellular aggregate
composed of heavily phosphorylated tau protein and extracellular deposit of amyloid-β (Aβ) …

Stem cell therapy for Alzheimer's disease: An overview of experimental models and reality

C Qin, K Wang, L Zhang, L Bai - Animal models and …, 2022 - Wiley Online Library
Alzheimer's disease (AD) is a neurodegenerative disorder. The pathology of AD is
characterized by extracellular amyloid beta (Aβ) plaques, neurofibrillary tangles composed …

Formulation development, characterization and antifungal evaluation of chitosan NPs for topical delivery of voriconazole in vitro and ex vivo

MKA Shah, AK Azad, A Nawaz, S Ullah, MS Latif… - Polymers, 2021 - mdpi.com
This study aims to develop chitosan-based voriconazole nanoparticles (NPs) using spray-
drying technique. The effect of surfactants and polymers on the physicochemical properties …

Inhibition of Butyrylcholinesterase and Human Monoamine Oxidase-B by the Coumarin Glycyrol and Liquiritigenin Isolated from Glycyrrhiza uralensis

GS Jeong, MG Kang, JY Lee, SR Lee, D Park, ML Cho… - Molecules, 2020 - mdpi.com
Eight compounds were isolated from the roots of Glycyrrhiza uralensis and tested for
cholinesterase (ChE) and monoamine oxidase (MAO) inhibitory activities. The coumarin …

Piperidine nucleus as a promising scaffold for alzheimer's disease: current landscape and future perspective

P Grover, S Rohilla, M Bhardwaj… - Current Topics in …, 2023 - ingentaconnect.com
Heterocycles and their derivatives hold an important place in medicinal chemistry due to
their vast therapeutic and pharmacological significance and wider implications in drug …

In Vitro and In Silico Evaluation of Anticholinesterase and Antidiabetic Effects of Furanolabdanes and Other Constituents from Graptophyllum pictum (Linn.) Griffith

NT Metiefeng, AN Tamfu, M Fotsing Tagatsing… - Molecules, 2023 - mdpi.com
Graptophyllum pictum is a tropical plant noticeable for its variegated leaves and exploited for
various medicinal purposes. In this study, seven compounds, including three furanolabdane …

Prospects of marine sterols against pathobiology of Alzheimer's disease: Pharmacological insights and technological advances

MA Rahman, R Dash, AAM Sohag, M Alam, H Rhim… - Marine Drugs, 2021 - mdpi.com
Alzheimer's disease (AD) is a degenerative brain disorder characterized by a progressive
decline in memory and cognition, mostly affecting the elderly. Numerous functional …