Machine learning for antimicrobial peptide identification and design

F Wan, F Wong, JJ Collins… - Nature Reviews …, 2024 - nature.com
Artificial intelligence (AI) and machine learning (ML) models are being deployed in many
domains of society and have recently reached the field of drug discovery. Given the …

Identification of antimicrobial peptides from the human gut microbiome using deep learning

Y Ma, Z Guo, B **a, Y Zhang, X Liu, Y Yu, N Tang… - Nature …, 2022 - nature.com
The human gut microbiome encodes a large variety of antimicrobial peptides (AMPs), but
the short lengths of AMPs pose a challenge for computational prediction. Here we combined …

[HTML][HTML] Enhancing antimicrobial peptide activity through modifications of charge, hydrophobicity, and structure

P Gagat, M Ostrówka, A Duda-Madej… - International Journal of …, 2024 - mdpi.com
Antimicrobial peptides (AMPs) are emerging as a promising alternative to traditional
antibiotics due to their ability to disturb bacterial membranes and/or their intracellular …

sAMPpred-GAT: prediction of antimicrobial peptide by graph attention network and predicted peptide structure

K Yan, H Lv, Y Guo, W Peng, B Liu - Bioinformatics, 2023 - academic.oup.com
Abstract Motivation Antimicrobial peptides (AMPs) are essential components of therapeutic
peptides for innate immunity. Researchers have developed several computational methods …

Comprehensive assessment of machine learning-based methods for predicting antimicrobial peptides

J Xu, F Li, A Leier, D **ang, HH Shen… - Briefings in …, 2021 - academic.oup.com
Antimicrobial peptides (AMPs) are a unique and diverse group of molecules that play a
crucial role in a myriad of biological processes and cellular functions. AMP-related studies …

[HTML][HTML] Discovery of antimicrobial peptides in the global microbiome with machine learning

CD Santos-Júnior, MDT Torres, Y Duan, ÁR Del Río… - Cell, 2024 - cell.com
Novel antibiotics are urgently needed to combat the antibiotic-resistance crisis. We present a
machine-learning-based approach to predict antimicrobial peptides (AMPs) within the global …

Machine learning prediction of antimicrobial peptides

G Wang, II Vaisman, ML van Hoek - Computational Peptide Science …, 2022 - Springer
Antibiotic resistance constitutes a global threat and could lead to a future pandemic. One
strategy is to develop a new generation of antimicrobials. Naturally occurring antimicrobial …

Benchmarks in antimicrobial peptide prediction are biased due to the selection of negative data

K Sidorczuk, P Gagat, F Pietluch, J Kała… - Briefings in …, 2022 - academic.oup.com
Antimicrobial peptides (AMPs) are a heterogeneous group of short polypeptides that target
not only microorganisms but also viruses and cancer cells. Due to their lower selection for …

A novel family of defensin-like peptides from Hermetia illucens with antibacterial properties

L Fahmy, T Generalovic, YM Ali, D Seilly, K Sivanesan… - BMC microbiology, 2024 - Springer
Background The world faces a major infectious disease challenge. Interest in the discovery,
design, or development of antimicrobial peptides (AMPs) as an alternative approach for the …

Perspectives in searching antimicrobial peptides (AMPs) produced by the microbiota

L Gallardo-Becerra, M Cervantes-Echeverría… - Microbial Ecology, 2024 - Springer
Abstract Changes in the structure and function of the microbiota are associated with various
human diseases. These microbial changes can be mediated by antimicrobial peptides …