Proliferative thyroid diseases are more prevalent in females than in males. Upon the onset of
puberty, the incidence of thyroid cancer increases in females only and declines again after …

Cancer cells bypass normal controls over mitotic cell-cycle progression to achieve a
deregulated state of proliferation. The retinoblastoma tumor suppressor protein (pRb) …

Purpose Abemaciclib, a cyclin-dependent kinase 4 and 6 inhibitor, demonstrated efficacy as
monotherapy and in combination with fulvestrant in women with hormone receptor (HR) …

Purpose MONARCH 2 (ClinicalTrials. gov identifier: NCT02107703) compared the efficacy
and safety of abemaciclib, a selective cyclin-dependent kinase 4 and 6 inhibitor, plus …

Abstract Purpose: The phase II MONARCH 1 study was designed to evaluate the single-
agent activity and adverse event (AE) profile of abemaciclib, a selective inhibitor of CDK4 …

This nonrandomized, open-label, multi-cohort Phase 1b study (NCT02779751) investigated
the safety and efficacy of abemaciclib plus pembrolizumab with/without anastrozole in …

Steroid hormones exert profound effects on cell growth, development, differentiation, and
homeostasis. Their effects are mediated through specific intracellular steroid receptors that …

Estrogen receptor (ER) binds to estrogen response elements in target genes and recruits a
coactivator complex of CBP-pl60 that mediates stimulation of transcription. ER also activates …

17β-Estradiol (E2) controls many aspects of human physiology, including development,
reproduction and homeostasis, through regulation of the transcriptional activity of its cognate …

Studies indicate that estrogen receptor (ER) α mediates breast cancer-promoting effects of
estrogens. The role of ERβ in breast cancer is unknown. Elucidating the role of ERβ in the …