[HTML][HTML] Assessment of cell cycle regulators in human peripheral blood cells as markers of cellular senescence
Cellular senescence has gained increasing interest during recent years, particularly due to
causal involvement in the aging process corroborated by multiple experimental findings …
causal involvement in the aging process corroborated by multiple experimental findings …
Free circulating miRNAs measurement in clinical settings: the still unsolved issue of the normalization
M Faraldi, M Gomarasca, G Banfi… - Advances in clinical …, 2018 - Elsevier
Circulating molecules that are released into the circulation in response to specific stimuli are
considered potential biomarkers for physiological or pathological processes. Their effective …
considered potential biomarkers for physiological or pathological processes. Their effective …
Use of high-sensitivity digital ELISA improves the diagnostic performance of circulating brain-specific proteins for detection of traumatic brain injury during triage
Background: Historically, limited sensitivity associated with traditional immunoassay
methods has prevented the use of brain-specific proteins as blood biomarkers of traumatic …
methods has prevented the use of brain-specific proteins as blood biomarkers of traumatic …
Bioinformatic analysis of brain-specific miRNAs for identification of candidate traumatic brain injury blood biomarkers
Background Detection of brain-specific miRNAs in the peripheral blood could serve as a
surrogate marker of traumatic brain injury (TBI). Here, we systematically identified brain …
surrogate marker of traumatic brain injury (TBI). Here, we systematically identified brain …
Variability in donor leukocyte counts confound the use of common RNA sequencing data normalization strategies in transcriptomic biomarker studies performed with …
GC O'Connell - Scientific Reports, 2023 - nature.com
Gene expression data generated from whole blood via next generation sequencing is
frequently used in studies aimed at identifying mRNA-based biomarker panels with utility for …
frequently used in studies aimed at identifying mRNA-based biomarker panels with utility for …
Rats lacking Ucp1 present a novel translational tool for the investigation of thermogenic adaptation during cold challenge
JD Warfel, CM Elks, DS Bayless… - Acta …, 2023 - Wiley Online Library
Aim Valuable studies have tested the role of UCP1 on body temperature maintenance in
mice, and we sought to knockout Ucp1 in rats (Ucp1−/−) to provide insight into thermogenic …
mice, and we sought to knockout Ucp1 in rats (Ucp1−/−) to provide insight into thermogenic …
Monocyte-lymphocyte cross-communication via soluble CD163 directly links innate immune system activation and adaptive immune system suppression following …
GC O'Connell, CS Tennant, N Lucke-Wold… - Scientific reports, 2017 - nature.com
CD163 is a scavenger receptor expressed on innate immune cell populations which can be
shed from the plasma membrane via the metalloprotease ADAM17 to generate a soluble …
shed from the plasma membrane via the metalloprotease ADAM17 to generate a soluble …
Diagnosis of ischemic stroke using circulating levels of brain-specific proteins measured via high-sensitivity digital ELISA
Limited lower detection ranges associated with traditional immunoassay techniques have
prevented the use of brain-specific proteins as blood biomarkers of stroke in the acute phase …
prevented the use of brain-specific proteins as blood biomarkers of stroke in the acute phase …
Genome-wide identification and evolution of the SAP gene family in sunflower (Helianthus annuus L.) and expression analysis under salt and drought stress
C Zhang, X Zhang, Y Wu, X Li, C Du, N Di, Y Chen - PeerJ, 2024 - peerj.com
Stress-associated proteins (SAPs) are known to play an important role in plant responses to
abiotic stresses. This study systematically identified members of the sunflower SAP gene …
abiotic stresses. This study systematically identified members of the sunflower SAP gene …
Shifts in leukocyte counts drive the differential expression of transcriptional stroke biomarkers in whole blood
GC O'Connell, MB Treadway, CS Tennant… - Translational stroke …, 2019 - Springer
Our group recently identified a panel of ten genes whose RNA expression levels in whole
blood have utility for detection of stroke. The purpose of this study was to determine the …
blood have utility for detection of stroke. The purpose of this study was to determine the …