The use of antibiotics in food animals selects for bacteria resistant to antibiotics used in
humans, and these might spread via the food to humans and cause human infection, hence …

Purpose An understanding of the pharmacokinetic (PK) and pharmacodynamic (PD)
principles that determine response to antimicrobial therapy can provide the clinician with …

Ulcerative colitis (UC) is often accompanied by intestinal inflammation and disruption of
intestinal epithelial structures, which are closely associated with changes in the intestinal …

Background Limitations of antifungal agents used in the treatment of oral candidiasis, as the
development of resistant strains, are known by the scientific community. In this context, the …

Staphylococcus aureus is often involved in severe infections, in which the effects of bacterial
virulence factors have great importance. Antistaphylococcal regimens should take into …

Background Clinical trials showed a single oral dose of doxycycline taken after sex protects
against STIs among men who have sex with men (MSM) but not women. Pharmacokinetic …

The steady-state concentrations of omadacycline and tigecycline in the plasma, epithelial
lining fluid (ELF), and alveolar cells (AC) of 58 healthy adult subjects were obtained …

ABSTRACT SCY-078 (MK-3118) is a novel, semisynthetic derivative of enfumafungin and
represents the first compound of the triterpene class of antifungals. SCY-078 exhibits potent …

Echinocandins have become a first-line therapy for invasive candidiasis (IC). Using phase 3
trial data for patients with IC, pharmacokinetic-pharmacodynamic (PK-PD) relationships for …

Pharmacokinetic and clinical data from tigecycline-treated patients with hospital-acquired
pneumonia (HAP) who were enrolled in a phase 3 clinical trial were integrated in order to …