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The JAK/STAT signaling pathway: from bench to clinic
X Hu, J Li, M Fu, X Zhao, W Wang - Signal transduction and targeted …, 2021 - nature.com
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …
Advances in covalent kinase inhibitors
Over the past decade, covalent kinase inhibitors (CKI) have seen a resurgence in drug
discovery. Covalency affords a unique set of advantages as well as challenges relative to …
discovery. Covalency affords a unique set of advantages as well as challenges relative to …
The gut microbiota reprograms intestinal lipid metabolism through long noncoding RNA Snhg9
The intestinal microbiota regulates mammalian lipid absorption, metabolism, and storage.
We report that the microbiota reprograms intestinal lipid metabolism in mice by repressing …
We report that the microbiota reprograms intestinal lipid metabolism in mice by repressing …
In vivo development of immune tissue in human intestinal organoids transplanted into humanized mice
Human intestinal organoids (HIOs) derived from pluripotent stem cells provide a valuable
model for investigating human intestinal organogenesis and physiology, but they lack the …
model for investigating human intestinal organogenesis and physiology, but they lack the …
S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis
L Deng, F Costa, KJ Blake, S Choi, A Chandrabalan… - Cell, 2023 - cell.com
Itch is an unpleasant sensation that evokes a desire to scratch. The skin barrier is constantly
exposed to microbes and their products. However, the role of microbes in itch generation is …
exposed to microbes and their products. However, the role of microbes in itch generation is …
A natural killer–dendritic cell axis defines checkpoint therapy–responsive tumor microenvironments
Intratumoral stimulatory dendritic cells (SDCs) play an important role in stimulating cytotoxic
T cells and driving immune responses against cancer. Understanding the mechanisms that …
T cells and driving immune responses against cancer. Understanding the mechanisms that …
Interrogating open issues in cancer precision medicine with patient-derived xenografts
Patient-derived xenografts (PDXs) have emerged as an important platform to elucidate new
treatments and biomarkers in oncology. PDX models are used to address clinically relevant …
treatments and biomarkers in oncology. PDX models are used to address clinically relevant …
Neuronal regulation of type 2 innate lymphoid cells via neuromedin U
Group 2 innate lymphoid cells (ILC2s) regulate inflammation, tissue repair and metabolic
homeostasis, and are activated by host-derived cytokines and alarmins. Discrete subsets of …
homeostasis, and are activated by host-derived cytokines and alarmins. Discrete subsets of …
Interleukin-22: immunobiology and pathology
Interleukin-22 (IL-22) is a recently described IL-10 family cytokine that is produced by T
helper (Th) 17 cells, γδ T cells, NKT cells, and newly described innate lymphoid cells (ILCs) …
helper (Th) 17 cells, γδ T cells, NKT cells, and newly described innate lymphoid cells (ILCs) …
[HTML][HTML] The generation and application of patient-derived xenograft model for cancer research
Establishing an appropriate preclinical model is crucial for translational cancer research.
The most common way that has been adopted by far is grafting cancer cell lines, derived …
The most common way that has been adopted by far is grafting cancer cell lines, derived …