Research conducted over the past several decades has revolutionized our understanding of
the role of the immune system in neural and psychological development and function across …

Importance The prevalence of and mortality associated with methamphetamine use has
doubled during the past 10 years. There is evidence suggesting that methamphetamine use …

Depression onset peaks during adolescence and young adulthood. Current treatments are
only moderately effective, driving the search for novel pathophysiological mechanisms …

Anhedonia, as evidenced by impaired pleasurable response to reward, reduced reward
motivation, and/or deficits in reward-related learning, is a common feature of depression …

Increased inflammation in major depressive disorder (MDD) has been associated with low
functional connectivity (FC) in corticostriatal reward circuits and symptoms of anhedonia …

Exogenous administration of inflammatory stimuli to humans and laboratory animals and
chronic endogenous inflammatory states lead to motivational deficits and ultimately …

Inflammatory cytokines have been shown to have a direct effect on mesolimbic dopamine
(DA) that is associated with a reduced willingness to expend effort for reward. To date …

Increased levels of peripheral cytokines have been previously associated with depression in
preclinical and clinical research. Although the precise nature of peripheral immune …

What do we know about sickness behavior? In this article, I guide you through some of the
complexity of sickness behavior occurring after an immune challenge. I highlight the many …

Depression is a serious public health problem, and adolescence is an 'age of risk'for the
onset of Major Depressive Disorder. Recently, we and others have proposed neuroimmune …