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Tumor microenvironment signaling and therapeutics in cancer progression
Tumor development and metastasis are facilitated by the complex interactions between
cancer cells and their microenvironment, which comprises stromal cells and extracellular …
cancer cells and their microenvironment, which comprises stromal cells and extracellular …
Therapeutic resistance to anti-oestrogen therapy in breast cancer
The hormone receptor oestrogen receptor-α (ER) orchestrates physiological mammary
gland development, breast carcinogenesis and the progression of breast tumours into lethal …
gland development, breast carcinogenesis and the progression of breast tumours into lethal …
Gut microbiota and cancer: from pathogenesis to therapy
Cancer is a multifactorial pathology and it represents the second leading cause of death
worldwide. In the recent years, numerous studies highlighted the dual role of the gut …
worldwide. In the recent years, numerous studies highlighted the dual role of the gut …
Estrogens and breast cancer: Mechanisms involved in obesity-related development, growth and progression
Obesity is a risk factor for estrogen receptor-positive (ER+) breast cancer after menopause.
The pro-proliferative effects of estrogens are well characterized and there is a growing body …
The pro-proliferative effects of estrogens are well characterized and there is a growing body …
LncRNA HOTAIR enhances ER signaling and confers tamoxifen resistance in breast cancer
Tamoxifen, an estrogen receptor (ER) antagonist, is the mainstay treatment of breast cancer
and the development of resistance represents a major obstacle for a cure. Although long …
and the development of resistance represents a major obstacle for a cure. Although long …
Enrichment map: a network-based method for gene-set enrichment visualization and interpretation
Background Gene-set enrichment analysis is a useful technique to help functionally
characterize large gene lists, such as the results of gene expression experiments. This …
characterize large gene lists, such as the results of gene expression experiments. This …
ERBB receptors and cancer: the complexity of targeted inhibitors
NE Hynes, HA Lane - Nature Reviews Cancer, 2005 - nature.com
ERBB receptor tyrosine kinases have important roles in human cancer. In particular, the
expression or activation of epidermal growth factor receptor and ERBB2 are altered in many …
expression or activation of epidermal growth factor receptor and ERBB2 are altered in many …
Biological determinants of endocrine resistance in breast cancer
EA Musgrove, RL Sutherland - Nature Reviews Cancer, 2009 - nature.com
Endocrine therapies targeting oestrogen action (anti-oestrogens, such as tamoxifen, and
aromatase inhibitors) decrease mortality from breast cancer, but their efficacy is limited by …
aromatase inhibitors) decrease mortality from breast cancer, but their efficacy is limited by …
Estrogen–gut microbiome axis: Physiological and clinical implications
Low levels of gonadal circulating estrogen observed in post-menopausal women can
adversely impact a diverse range of physiological factors, with clinical implications for brain …
adversely impact a diverse range of physiological factors, with clinical implications for brain …
Characterizing DNA methylation signatures of retinoblastoma using aqueous humor liquid biopsy
Retinoblastoma (RB) is a cancer that forms in the develo** retina of babies and toddlers.
The goal of therapy is to cure the tumor, save the eye and maximize vision. However, it is …
The goal of therapy is to cure the tumor, save the eye and maximize vision. However, it is …