In biomedical sciences, the function of a protein of interest is investigated by altering its net
activity and assessing the consequences for the cell or organism. To change the activity of a …

Parasitic protozoa comprise diverse aetiological agents responsible for important diseases
in humans and animals including slee** sickness, Chagas disease, leishmaniasis …

Human protozoan diseases represent a serious health problem worldwide, affecting mainly
people in social and economic vulnerability. These diseases have attracted little investment …

A novel series of indole and benzimidazole bichalcophene diamidine derivatives were
prepared to study their antimicrobial activity against the tropical parasites causing African …

The fluorescent probe 4′, 6-diamidino-2-phenylindole (DAPI) is a dye known to interact
with polynucleotides in a non-univocal manner, both intercalation and minor groove binding …

Combining the hybridization and repurposing strategies, six compounds from our in-house
library and having a designed hybrid structure of MBX-1162, pentamidine and MMV688271 …

Small molecule complexes with DNA that incorporate linking water molecules are rare, and
the DB921-DNA complex has provided a unique and well-defined system for analysis of …

A highly regioselective alkynylation of indoles has been accomplished for the assembly of
functionalized C2 alkynylindoles in moderate to good yields with a primary amine as the …

In spite of its importance in cell function, targeting DNA is under‐represented in the design of
small molecules. A barrier to progress in this area is the lack of a variety of modules that …

The continuing need for the discovery of potent antibacterial agents against antibiotic-
resistant pathogens is the driving force for many researchers to design and develop such …