Targeting memory T cell metabolism to improve immunity
Vaccination affords protection from disease by activating pathogen-specific immune cells
and facilitating the development of persistent immunologic memory toward the vaccine …
and facilitating the development of persistent immunologic memory toward the vaccine …
Regulation of effector and memory CD8 T cell differentiation by IL-2—a balancing act
Interleukin-2 (IL-2) regulates key aspects of CD8 T cell biology–signaling through distinct
pathways IL-2 triggers critical metabolic and transcriptional changes that lead to a spectrum …
pathways IL-2 triggers critical metabolic and transcriptional changes that lead to a spectrum …
A next-generation tumor-targeting IL-2 preferentially promotes tumor-infiltrating CD8+ T-cell response and effective tumor control
While IL-2 can potently activate both NK and T cells, its short in vivo half-life, severe toxicity,
and propensity to amplify Treg cells are major barriers that prevent IL-2 from being widely …
and propensity to amplify Treg cells are major barriers that prevent IL-2 from being widely …
Regulatory T cells impede acute and long-term immunity to blood-stage malaria through CTLA-4
Malaria, caused by the protozoan Plasmodium, is a devastating mosquito-borne disease
with the potential to affect nearly half the world's population. Despite mounting substantial T …
with the potential to affect nearly half the world's population. Despite mounting substantial T …
Cytokine-mediated regulation of CD8 T-cell responses during acute and chronic viral infection
The common γ-chain cytokines, interleukin (IL)-2, IL-7, and IL-15, regulate critical aspects of
antiviral CD8 T-cell responses. During acute infections, IL-2 controls expansion and …
antiviral CD8 T-cell responses. During acute infections, IL-2 controls expansion and …
Listeria monocytogenes-induced cell death inhibits the generation of cell-mediated immunity
E Theisen, JD Sauer - Infection and Immunity, 2017 - Am Soc Microbiol
The influence of cell death on adaptive immunity has been studied for decades. Despite
these efforts, the intricacies of how various cell death pathways shape immune responses in …
these efforts, the intricacies of how various cell death pathways shape immune responses in …
Genome-wide transcriptional profiling and functional analysis of long noncoding RNAs and mRNAs in chicken macrophages associated with the infection of avian …
H Sun, X Cao, Sumayya, Y Ma, H Li, W Han… - BMC Veterinary …, 2024 - Springer
Background Avian pathogenic E. coli (APEC) can cause localized or systemic infections,
collectively known as avian colibacillosis, resulting in huge economic losses to poultry …
collectively known as avian colibacillosis, resulting in huge economic losses to poultry …
Prophylactic vaccines for nonviral cancers
BA Scott, M Yarchoan, EM Jaffee - Annual Review of Cancer …, 2018 - annualreviews.org
The successful development of prophylactic cancer vaccines targeting oncogenic viruses
has demonstrated the potential for vaccination to reduce the global burden of cancer …
has demonstrated the potential for vaccination to reduce the global burden of cancer …
Adenovirus-mediated OX40Ig gene transfer induces long-term survival of orthotopic liver allograft in rats
Z Chen, C Wang, F Wei, B Xu, J Liu, Y Pu, S Zhang… - Transplant …, 2018 - Elsevier
Background To discuss the effect and mechanism of adenovirus-mediated OX40Ig gene
transfer in inducing long-term survival of liver allografts in rats. Methods Orthotopic liver …
transfer in inducing long-term survival of liver allografts in rats. Methods Orthotopic liver …
Personalized ex vivo multiple peptide enrichment and detection of T cells reactive to multiple tumor-associated antigens in prostate cancer patients
P Taborska, D Stakheev, Z Strizova, K Vavrova… - Medical oncology, 2017 - Springer
Personalized peptide vaccination is a promising immunotherapeutic approach in prostate
cancer (PCa). We therefore examined whether an approach, utilizing personalized multiple …
cancer (PCa). We therefore examined whether an approach, utilizing personalized multiple …