Reversible protein phosphorylation plays a central role in regulating intracellular signaling.
Dysregulation of the mechanisms that regulate phosphorylation plays a direct role in cancer …

SUMMARY Simian virus 40 (SV40) is a small DNA tumor virus that has been extensively
characterized due to its relatively simple genetic organization and the ease with which its …

Merkel cell polyomavirus (MCV) is the recently discovered cause of most Merkel cell
carcinomas (MCCs), an aggressive form of nonmelanoma skin cancer. Although MCV is …

Recent studies have demonstrated that introduction of hTERT in combination with SV40
large T antigen (LT), small t antigen (st), and H-rasV12 suffices to transform many primary …

Although the small DNA tumor virus SV40 (simian virus 40) fails to replicate in human cells,
understanding how SV40 transforms human and murine cells has and continues to provide …

Mesothelioma, a malignancy associated with asbestos, has been recently linked to simian
virus 40 (SV40). We found that infection of human mesothelial cells by SV40 is very different …

Human diploid cells have a limited life span, ending in replicative senescence, in contrast to
cell lines derived from tumors, which show an indefinite life span and are immortal …

Merkel cell polyomavirus (MCV) is a recently discovered human polyomavirus causing the
majority of human Merkel cell carcinomas. We mapped a 71-bp minimal MCV replication …

Simian Virus 40 (SV40) and Mouse Polyoma Virus (PY) are small DNA tumor viruses that
have been used extensively to study cellular transformation. The SV40 early region encodes …

Simian virus 40 (SV40) encodes two proteins, large T antigen and small t antigen that
contribute to virus-induced tumorigenesis. Both proteins act by targeting key cellular …