Extracellular vesicles derived from neural stem cells, astrocytes, and microglia as therapeutics for easing TBI-induced brain dysfunction

C Hering, AK Shetty - Stem cells translational medicine, 2023 - academic.oup.com
Extracellular vesicles (EVs) derived from neural stem cells (NSC-EVs), astrocytes (ADEVs),
and microglia (MDEVs) have neuroregenerative properties. This review discusses the …

Nanotherapeutic and stem cell therapeutic strategies in neurodegenerative diseases: A promising therapeutic approach

M Wei, Z Yang, S Li, W Le - International journal of nanomedicine, 2023 - Taylor & Francis
Neurodegeneration is characterized by progressive, disabling, and incurable neurological
disorders with the massive loss of specific neurons. As one of the most promising potential …

Akebia saponin D protects hippocampal neurogenesis from microglia-mediated inflammation and ameliorates depressive-like behaviors and cognitive impairment in …

Q Liu, J Zhang, C **ao, D Su, L Li, C Yang… - Frontiers in …, 2022 - frontiersin.org
Given the ability of akebia saponin D (ASD) to protect various types of stem cells, in the
present study, we hypothesized that ASD could promote the proliferation, differentiation, and …

[HTML][HTML] Animal models of epilepsy: a phenotype-oriented review

Y Wang, P Wei, F Yan, Y Luo, G Zhao - Aging and disease, 2022 - ncbi.nlm.nih.gov
Epilepsy is a serious neurological disorder characterized by abnormal, recurrent, and
synchronous discharges in the brain. Long-term recurrent seizure attacks can cause serious …

Stem cell therapy in treating epilepsy

BL Chang, KH Chang - Frontiers in neuroscience, 2022 - frontiersin.org
Epilepsy is a common disabling chronic neurological disorder characterized by an enduring
propensity for the generation of seizures that result from abnormal hypersynchronous firing …

The role of brain-derived neurotrophic factor in epileptogenesis: an update

X Wang, Z Hu, K Zhong - Frontiers in Pharmacology, 2021 - frontiersin.org
Epilepsy, which is characterized by spontaneous recurrent seizures, is one of the most
common and serious chronic neurological diseases in the world. 30% patients failed to …

Stem cell-based therapeutic and diagnostic approaches in Alzheimer's disease

S Abdi, N Javanmehr… - Current …, 2022 - benthamdirect.com
Background: Alzheimer's disease (AD) is a neurodegenerative impairment mainly
recognized by memory loss and cognitive deficits. However, the current therapies against …

Grafted hPSC-derived GABA-ergic interneurons regulate seizures and specific cognitive function in temporal lobe epilepsy

D Upadhya, S Attaluri, Y Liu, B Hattiangady… - npj Regenerative …, 2022 - nature.com
Interneuron loss/dysfunction contributes to spontaneous recurrent seizures (SRS) in chronic
temporal lobe epilepsy (TLE), and interneuron grafting into the epileptic hippocampus …

Baicalin rescues cognitive dysfunction, mitigates neurodegeneration, and exerts anti-epileptic effects through activating TLR4/MYD88/caspase-3 pathway in rats

J Yang, Z Jia, Z **ao, J Zhao, Y Lu, L Chu… - Drug Design …, 2021 - Taylor & Francis
Purpose This study aims to evaluate the beneficial effects of anti-epileptic mechanisms of
baicalin (BA) on cognitive dysfunction and neurodegeneration in pentylenetetrazol (PTZ) …

[HTML][HTML] The gut microbiome and adult hippocampal neurogenesis: A new focal point for epilepsy?

S Dohm-Hansen, F Donoso, PJ Lucassen… - Neurobiology of …, 2022 - Elsevier
Temporal lobe epilepsy (TLE) is a neurological disorder affecting millions of people
worldwide and currently represents the most common form of focal epilepsy. Thus, the …