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Human organoids in basic research and clinical applications
Organoids are three-dimensional (3D) miniature structures cultured in vitro produced from
either human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) derived from …
either human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) derived from …
Controlling the polarity of human gastrointestinal organoids to investigate epithelial biology and infectious diseases
Human epithelial organoids—3D spheroids derived from adult tissue stem cells—enable
investigation of epithelial physiology and disease and host interactions with …
investigation of epithelial physiology and disease and host interactions with …
Gut microbiota and colonization resistance against bacterial enteric infection
The gut microbiome is critical in providing resistance against colonization by exogenous
microorganisms. The mechanisms via which the gut microbiota provide colonization …
microorganisms. The mechanisms via which the gut microbiota provide colonization …
[HTML][HTML] Gut microbiota and intestinal trans-epithelial permeability
B Allam-Ndoul, S Castonguay-Paradis… - International journal of …, 2020 - mdpi.com
Constant remodeling of tight junctions to regulate trans-epithelial permeability is essential in
maintaining intestinal barrier functions and thus preventing diffusion of small molecules and …
maintaining intestinal barrier functions and thus preventing diffusion of small molecules and …
[HTML][HTML] Small intestine microbiota regulate host digestive and absorptive adaptive responses to dietary lipids
K Martinez-Guryn, N Hubert, K Frazier, S Urlass… - Cell host & …, 2018 - cell.com
The gut microbiota play important roles in lipid metabolism and absorption. However, the
contribution of the small bowel microbiota of mammals to these diet-microbe interactions …
contribution of the small bowel microbiota of mammals to these diet-microbe interactions …
The intestinal epithelial barrier: a therapeutic target?
A fundamental function of the intestinal epithelium is to act as a barrier that limits interactions
between luminal contents such as the intestinal microbiota, the underlying immune system …
between luminal contents such as the intestinal microbiota, the underlying immune system …
[HTML][HTML] Organoids and organs-on-chips: Insights into human gut-microbe interactions
The important and diverse roles of the gut microbiota in human health and disease are
increasingly recognized. The difficulty of inferring causation from metagenomic microbiome …
increasingly recognized. The difficulty of inferring causation from metagenomic microbiome …
Modelling Cryptosporidium infection in human small intestinal and lung organoids
Stem-cell-derived organoids recapitulate in vivo physiology of their original tissues,
representing valuable systems to model medical disorders such as infectious diseases …
representing valuable systems to model medical disorders such as infectious diseases …
A primary human macrophage-enteroid co-culture model to investigate mucosal gut physiology and host-pathogen interactions
Integration of the intestinal epithelium and the mucosal immune system is critical for gut
homeostasis. The intestinal epithelium is a functional barrier that secludes luminal content …
homeostasis. The intestinal epithelium is a functional barrier that secludes luminal content …
IL1B increases intestinal tight junction permeability by up-regulation of MIR200C-3p, which degrades occludin mRNA
Background & Aims Defects in the epithelial tight junction (TJ) barrier contribute to
development of intestinal inflammation associated with diseases. Interleukin 1 beta (IL1B) …
development of intestinal inflammation associated with diseases. Interleukin 1 beta (IL1B) …