Genomic instability is the hallmark of various cancers with the increasing accumulation of
DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is …

Background Coumarins, abundantly distributed in a plethora of biologically active
compounds, serve as a fundamental motif in numerous natural products, drugs, and …

Natural coumarins and isocoumarins show significant therapeutic potential against cancer in
preclinical studies by targeting multiple pathways and processes. These compounds …

Base excision repair (BER) repairs mutagenic or genotoxic DNA base lesions, thought to be
important for both the etiology and treatment of cancer. Cancer phenotypic stress induces …

Steroids are polycyclic compounds and are broadly exist in the natural world and display
various biological activities. Many steroidal compounds have been used as traditional …

In this study, new cytotoxic agents based on 2-aminobenzamide scaffold were designed,
synthesized and evaluated against A549, HCT116 and HT-29 cancer cell lines (inhib%) in …

Triple-negative breast cancer (TNBC) is considered the most aggressive breast cancer
subtype, shows a poor response to the currently available therapy, and has no targeted …

Breast cancer is the most common invasive cancer in women, and the second main cause of
deaths in women, after lung cancer. There is continuous advancement in the development of …

The emergence of drug resistance, coupled with the issue of low tumor selectivity and
toxicity is a major pitfall in cancer chemotherapy. It has necessitated the urgent need for the …

Alzheimer's disease (AD) is a leading neurodegenerative disorder recognized by
progressive cognitive decline and behavioral changes. The pathology of AD is characterized …