Glutamine is an essential cerebral metabolite. Several critical brain processes are directly
linked to glutamine, including ammonia homeostasis, energy metabolism and …

Neuronal plasticity is critical for the maintenance and modulation of brain activity. Emerging
evidence indicates that glial cells actively shape neuroplasticity, allowing for highly flexible …

Pulmonary fibrosis (PF) is a lethal fibrotic lung disease. The role of lncRNAs in multiple
diseases has been confirmed, but the role and mechanism of lncRNA zinc finger antisense 1 …

Synaptic regulation of the primary inhibitory neurotransmitter γ-aminobutyric acid (GABA) is
essential for brain function. Cerebral GABA homeostasis is tightly regulated through multiple …

Elevated blood ammonia (hyperammonemia) is believed to be a major contributor to the
neurological sequelae following severe liver disease. Ammonia is cleared via two main …

Fibrosis refers to the process of excessive deposition of extracellular matrix (ECM) proteins,
eventually leading to excessive scar formation. Fibrotic diseases can occur in many organs …

Autism spectrum disorder (ASD) is a highly heterogeneous disorder, yet transcriptomic
profiling of bulk brain tissue has identified substantial convergence among dysregulated …

Ferroptosis is a novel form of programmed cell death caused by damage to lipid membranes
due to the accumulation of lipid peroxides in response to various stimuli, such as high levels …

Amino acids are essential for cellular protein synthesis, growth, metabolism, signaling and in
stress responses. Cell plasma membranes harbor specialized transporters accumulating …

Ferroptosis is a newly recognized form of cell death that is distinct from apoptosis, necrosis,
autophagy in morphology, biochemistry, and heredity. The basic process of ferroptosis …