Brain function critically relies on blood vessels to supply oxygen and nutrients, to establish a
barrier for neurotoxic substances, and to clear waste products. The archetypal vascular …

There is increasing evidence that cerebrovascular dysfunction plays a role not only in
vascular causes of cognitive impairment but also in Alzheimer's disease (AD). Vascular risk …

Alzheimer's disease (AD) is the most prevalent form of dementia. Despite decades of
research following several theoretical and clinical lines, all existing treatments for the …

Recent studies implicate loss of pericytes in hypoperfusion and blood–brain barrier (BBB)
leakage in Alzheimer's disease (AD). In this study, we have measured levels of the pericyte …

Structural and functional integrity of the cerebral vasculature ensures proper brain
development and function, as well as healthy aging. The inability of the brain to store energy …

The etiology of Alzheimer's disease (AD) remains unclear. The emerging view is that
cerebrovascular dysfunction is a feature not only of cerebrovascular diseases, such as …

Perfusion is reduced in the cerebral neocortex in Alzheimer's disease. We have explored
some of the mechanisms, by measurement of perfusion-sensitive and disease-related …

At first sight, the nervous and vascular systems seem to share little in common. However,
neural and vascular cells not only are anatomically closely tied to each other, but they also …

Neurovascular dysfunction, as an integral part of Alzheimer's disease, may have an
important influence on the onset and progression of chronic neurodegenerative processes …

Background Clinicopathological studies suggest that Alzheimer's disease (AD) pathology
begins∼ 10–15 years before the resulting cognitive impairment draws medical attention …