Endothelium structure and function in kidney health and disease
N Jourde-Chiche, F Fakhouri, L Dou, J Bellien… - Nature Reviews …, 2019 - nature.com
The kidney harbours different types of endothelia, each with specific structural and functional
characteristics. The glomerular endothelium, which is highly fenestrated and covered by a …
characteristics. The glomerular endothelium, which is highly fenestrated and covered by a …
Immune cell dysfunction and inflammation in end-stage renal disease
MGH Betjes - Nature Reviews Nephrology, 2013 - nature.com
Uraemia causes inflammation and reduces immune system function as evidenced by an
increased risk of viral-associated cancers, increased susceptibility to infections and …
increased risk of viral-associated cancers, increased susceptibility to infections and …
FGF23 signalling and physiology
BB Ho, C Bergwitz - Journal of molecular endocrinology, 2021 - jme.bioscientifica.com
Fibroblast growth factor 23 (FGF23) is a phosphotropic hormone that belongs to a subfamily
of endocrine FGFs with evolutionarily conserved functions in worms and fruit flies. FAM20C …
of endocrine FGFs with evolutionarily conserved functions in worms and fruit flies. FAM20C …
FGF23 signaling impairs neutrophil recruitment and host defense during CKD
J Rossaint, J Oehmichen, H Van Aken… - The Journal of …, 2016 - Am Soc Clin Investig
Chronic kidney disease (CKD) has been associated with impaired host response and
increased susceptibility to infections. Leukocyte recruitment during inflammation must be …
increased susceptibility to infections. Leukocyte recruitment during inflammation must be …
Association of serum bicarbonate with risk of renal and cardiovascular outcomes in CKD: a report from the Chronic Renal Insufficiency Cohort (CRIC) study
Background The purpose of this study is to evaluate serum bicarbonate level as a risk factor
for renal outcomes, cardiovascular events, and mortality in patients with chronic kidney …
for renal outcomes, cardiovascular events, and mortality in patients with chronic kidney …
Cellular biomarkers of endothelial health: microparticles, endothelial progenitor cells, and circulating endothelial cells
Endothelial dysfunction, the shift from a healthy endothelium to a damaged pro-coagulative,
pro-inflammatory, and pro-vasoconstrictive phenotype, is an early event in many chronic …
pro-inflammatory, and pro-vasoconstrictive phenotype, is an early event in many chronic …
The role of endothelial glycocalyx in health and disease
The endothelium is the largest organ in the body and recent studies have shown that the
endothelial glycocalyx (eGCX) plays a major role in health and disease states. The integrity …
endothelial glycocalyx (eGCX) plays a major role in health and disease states. The integrity …
Uremic toxins, oxidative stress, atherosclerosis in chronic kidney disease, and kidney transplantation
E Wojtaszek, U Oldakowska-Jedynak… - oxidative medicine …, 2021 - Wiley Online Library
Patients with chronic kidney disease (CKD) are at a high risk for cardiovascular disease
(CVD), and approximately half of all deaths among patients with CKD are a direct result of …
(CVD), and approximately half of all deaths among patients with CKD are a direct result of …
Atrial fibrillation and thromboembolism in patients with chronic kidney disease
YC Lau, M Proietti, E Guiducci, AD Blann… - Journal of the American …, 2016 - jacc.org
A bidirectional relationship exists between atrial fibrillation (AF) and chronic renal disease.
Patients with AF have a higher incidence of renal dysfunction, and the latter predisposes to …
Patients with AF have a higher incidence of renal dysfunction, and the latter predisposes to …
Oxidative stress–chronic kidney disease–cardiovascular disease: A vicious circle
Chronic kidney disease patient's progression to end-stage renal disease as well as their
high mortality are linked to cardiovascular disease. However, the high incidence rate of …
high mortality are linked to cardiovascular disease. However, the high incidence rate of …