Dysfunction of cell bioenergetics is a common feature of neurodegenerative diseases, the
most common of which is Alzheimer's disease (AD). Disrupted energy utilization implicates …

Ten years ago we first proposed the Alzheimer's disease (AD) mitochondrial cascade
hypothesis. This hypothesis maintains that gene inheritance defines an individual's baseline …

Estrogen is a fundamental regulator of the metabolic system of the female brain and body.
Within the brain, estrogen regulates glucose transport, aerobic glycolysis, and mitochondrial …

The literature on large‐scale resting‐state functional brain networks across the adult
lifespan was systematically reviewed. Studies published between 1986 and July 2021 were …

Inter‐hemispheric asymmetries are a common phenomenon of the human brain. Some
evidence suggests that neurodegeneration related to aging and disease may preferentially …

Numerous studies have established that estimated brain age constitutes a valuable
biomarker that is predictive of cognitive decline and various neurological diseases. In this …

Cognitive reserve (CR) and brain reserve (BR) are protective factors against age‐associated
cognitive decline and neurodegenerative disorders. Very limited evidence exists about …

Ageing entails cognitive and motor decline as well as brain changes such as loss of gray
(GM) and white matter (WM) integrity, neurovascular and functional connectivity alterations …

Objectives: The objective was to review the literature on diffusion tensor imaging as well as
resting-state functional magnetic resonance imaging and electroencephalography (EEG) to …

Normal brain aging is commonly associated with neural activity alteration, β-amyloid (Aβ)
deposition, and tau aggregation, driving a progressive cognitive decline in normal elderly …