Hypoxia is a state of low oxygen tension found in numerous solid tumours. It is typically
associated with abnormal vasculature, which results in a reduced supply of oxygen and …

Encouraged by the worldwide success of cisplatin in the field of cancer chemotherapy,
intensive works have been conducted to explore more platinum coordination complexes as …

Platinum-based drugs have maintained their preeminent position in cancer treatment
regimens even four decades after the approval of cisplatin. Although these agents have …

Owing to the distinctive constituents of tumor tissue from those healthy organs,
nanomedicine strategies show significant potentials in smart drug delivery. Nowadays …

Hypoxia and the acidic microenvironment play a vital role in tumor metastasis and
angiogenesis, generally compromising the chemotherapeutic efficacy. This provides a …

We report herein the design, synthesis, and biological investigation of a series of novel Pt
(IV) prodrugs with non-steroidal anti-inflammatory drugs naproxen, diclofenac, and …

Hypoxia is a known feature of aggressive solid tumors as well as a critical hallmark of the
niche in aggressive hematologic malignances. Hypoxia is associated with insufficient …

Platinum (IV) anticancer agents have demonstrated the potential to overcome the limitations
associated with the widely used Pt (II) chemotherapeutics, cisplatin, carboplatin, and …

Hypoxia is a hallmark of malignant tumors and often correlates with increasing tumor
aggressiveness and poor treatment outcomes. Therefore, early diagnosis and effective …

Classical platinum (II) anticancer agents are widely-used chemotherapeutic drugs in the
clinic against a range of cancers. However, severe systemic toxicity and drug resistance …