The primary goal of cytokinesis is to produce two daughter cells, each having a full set of
chromosomes. To achieve this, cells assemble a dynamic structure between segregated …

The neural crest gives rise to numerous cell types, dysfunction of which contributes to many
disorders. Here, we report that adenosine deaminase acting on RNA (ADAR1), responsible …

Heparanase is a heparan sulfate degrading enzyme that cleaves heparan sulfate (HS)
chains present on HS proteoglycans (HSPGs), and has been well characterized for its roles …

Growth factor (GF) delivery is a common strategy for spinal cord injury repair, however, GF
degradation can impede long‐term therapies. GF sequestration via heparin is known to …

Myelination is one of the most remarkable biological events in the neuron–glia interactions
for the development of the mammalian nervous system. To elucidate molecular mechanisms …

Axon degeneration underlies many nervous system diseases; therefore understanding the
regulatory signalling pathways is fundamental to identifying potential therapeutics …

Neuregulin1 (NRG1) is a growth factor playing a pivotal role in peripheral nerve
development through the activation of the transmembrane co-receptors ErbB2–ErbB3 …

In vitro cell-based assays have been fundamental in modern drug discovery and have led to
the identification of novel therapeutics. We have developed complex mixed central nervous …

Over 17,000 people per year in the United States sustain a spinal cord injury (SCI) for which
there is no gold standard of care and life-long complications. SCI is a complex wound …

היפוסוליפל רוטקוד Page 1 Thesis for the degree Doctor of Philosophy By Ary Shaviv Advisor:
Professor Dmitry Gourevitch April 2019 Submitted to the Scientific Council of the Weizmann …