Variation in the mitochondrial DNA (mtDNA) sequence is common in certain tumours. Two
classes of cancer mtDNA variants can be identified: de novo mutations that act as 'inducers' …

Mitochondria were first postulated to contribute to aging more than 40 years ago. During the
following decades, multiple lines of evidence in model organisms and humans showed that …

Contrary to conventional wisdom, functional mitochondria are essential for the cancer cell.
Although mutations in mitochondrial genes are common in cancer cells, they do not …

Cancer stem cells (CSCs) are a small and elusive subpopulation of self-renewing cancer
cells with remarkable ability to initiate, propagate, and spread the malignant disease. In …

Oncocytic cell tumors are characterized by the accumulation of morphologically abnormal
mitochondria in their cells, suggesting a role for abnormal mitochondrial biogenesis in …

Several mutations in nuclear genes encoding for mitochondrial components have been
associated with an increased cancer risk or are even causative, eg succinate …

Simple Summary Recent research suggests a strong link between the functioning of
mitochondria and the development of cancer. Healthy mitochondria play a vital role in …

Somatic mutations in the nuclear genome are required for tumor formation, but the functional
consequences of somatic mitochondrial DNA (mtDNA) mutations are less understood. Here …

Mitochondria from normal and cancerous cells represent a tale of two cities, wherein both
execute similar processes but with different cellular and molecular effects. Given the number …

Mitochondrial DNA (mtDNA) is as a double-stranded molecule existing in hundreds to
thousands copies in cells depending on cell metabolism and exposure to endogenous …