SARS-CoV-2 variants acquire mutations in the spike protein that promote immune evasion
and affect other properties that contribute to viral fitness, such as ACE2 receptor binding and …

Allosteric mechanisms are commonly employed regulatory tools used by proteins to
orchestrate complex biochemical processes and control communications in cells. The …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the devastating global COVID-19 pandemic announced by WHO in March 2020. Through …

The most recent wave of SARS-CoV-2 Omicron variants descending from BA. 2 and BA.
2.86 exhibited improved viral growth and fitness due to convergent evolution of functional …

The trimeric spike (S) glycoprotein, which protrudes from the SARS-CoV-2 viral envelope,
binds to human ACE2, initiated by at least one protomer's receptor binding domain (RBD) …

Evolutionary and functional studies suggested that the emergence of the Omicron variants
can be determined by multiple fitness trade-offs including the immune escape, binding …

The new generation of SARS-CoV-2 Omicron variants displayed a significant growth
advantage and increased viral fitness by acquiring convergent mutations, suggesting that …

GENeralized-Ensemble SImulation System (GENESIS) is a molecular dynamics (MD)
software developed to simulate the conformational dynamics of a single biomolecule, as …

SARS-CoV-2 variants acquire mutations in spike that promote immune evasion and impact
other properties that contribute to viral fitness such as ACE2 receptor binding and cell entry …

The latest wave of SARS-CoV-2 Omicron variants displayed a growth advantage and
increased viral fitness through convergent evolution of functional hotspots that work …