The calcium ion (Ca2+) is the simplest and most versatile intracellular messenger known.
The discovery of Ca2+ sparks and a related family of elementary Ca2+ signaling events has …

Spontaneous Ca2+ release from intracellular stores is important for various physiological
and pathological processes. In cardiac muscle cells, spontaneous store overload–induced …

Efficient intracellular Ca2+ ([Ca2+] i) homeostasis in skeletal muscle requires intact triad
junctional complexes comprised of t-tubule invaginations of plasma membrane and terminal …

Skeletal muscle fibres support store-operated Ca 2+-entry (SOCE) across the t-tubular
membrane upon exhaustive depletion of Ca 2+ from the sarcoplasmic reticulum (SR) …

The contractile cycle of striated muscles, skeletal and cardiac, is controlled by a cytosolic [Ca
2+] transient that requires rapid movements of the ion through channels in the sarcoplasmic …

Key points Tonic contractions of rabbit urethra are associated with spontaneous electrical
slow waves that are thought to originate in pacemaker cells termed interstitial cells of Cajal …

Abstract Ryanodine receptors (RyRs) are Ca 2+ release channels, gated by Ca 2+ in the
cytosol and the sarcoplasmic reticulum lumen. Their regulation is impaired in certain cardiac …

Atrial myocytes that lack t-tubules appear to have two functionally separate sarcoplasmic
Ca2+ stores: a peripheral store associated with plasmalemmal L-type calcium channels and …

Arterial smooth muscle (SM) cells respond autonomously to changes in intravascular
pressure, adjusting tension to maintain vessel diameter. The values of membrane potential …

Key points Accumulation of inorganic phosphate (Pi) may contribute to muscle fatigue by
precipitating calcium salts inside the sarcoplasmic reticulum (SR). Neither direct …